Abstract
The discovery that animals can immunologicaly recognize tumor transplants from syngeneic animals led to the search for antigens unique to spontaneously arising tumor cells. Production of antibodies to such putative tumor-specific antigens (TSAs) or tumor-associated antigens (TAAs) by conventional immunization, has been largely unsuccessful. However, the requisite specificity and molecular homogeneity of monoclonal antibody preparations has given new life to the search for TAAs.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ballou B, Reiland JM, Levine G, Taylor RJ, Shen W, Ryser HJ, Solter D, Hakala Tr: Tumor location and trug targeting using a monoclonal antibody (anti-SSEA-1) and antigen-binding fragments. J Surg Oncology 31: 1, 1986
Viola MV, Fromowitz F, Oravez S, Deb S, Schlom J: Ras oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma. J Exp Med 161: 1213, 1985
Morrison SL: Transfectomas provide novel chimeric antibodies. Science 229: 1202, 1985
Lee VK, Harriott TG, Kuchroo VK, Halliday WJ, Hellstrom I, Hellstrom KE: Monoclonal antiidiotypic antibodies related to a oncofetal bladder tumor antigen induce specific cell-mediated tumor immunity. Proc Natl Acad Sci USA 82: 6286, 1985
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishers, Boston
About this chapter
Cite this chapter
Hakala, T.R. (1987). Editorial Comment. In: Ratliff, T.L., Catalona, W.J. (eds) Genitourinary Cancer. Cancer Treatment and Research, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2033-3_14
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2033-3_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9210-4
Online ISBN: 978-1-4613-2033-3
eBook Packages: Springer Book Archive