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Modification of Membrane Function by Drugs

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Membrane Physiology

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Abstract

The importance of the surface membrane of cells as the primary site of action of many drugs has been obvious since the earliest appreciation of membranes as regulatory barriers. As soon as the permeability characteristics of cells became apparent, investigators reasoned that polar and highly water-soluble agents were unlikely to gain access to the inner plasma of cells. The rapid action of many of these compounds similarly argued for the cell surface as a probable site of action. Ingenious quantitative analyses by A. J. Claris(1) showed that most drugs are maximally effective when occupying only a small fraction of the total surface area available. Thus, the concept of specific recognition sites or receptors in (or on) the membrane was introduced. With very little modification, this concept remains today as a cornerstone principle of the basic mechanisms of drug action. Even agents that do not act through “classical” receptor mechanisms (e.g., the anesthetics discussed herein) produce their pharmacological actions by modifying membrane function. It is becoming increasingly apparent that the actions of most (if not all) pharmacological agents involve modification of membrane functions either directly or indirectly. Thus, the actions of drugs on membrane functions can be considered a fundamental aspect of drug action important in virtually all areas of pharmacology.

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, Medical College of Ohio, 43699, Toledo, Ohio, USA

    James W. Putney Jr.

  2. Department of Pharmacology, Medical College of Virginia, 23298, Richmond, Virginia, USA

    Howard C. Rosenberg, Ted H. Chiu & Amir Askari

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  1. Howard C. Rosenberg
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  2. Ted H. Chiu
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  3. James W. Putney Jr.
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  4. Amir Askari
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Editor information

Editors and Affiliations

  1. Department of Physiology and Cell Biology, University of Texas Medical School, 77225, Houston, Texas, USA

    Thomas E. Andreoli M.D. (Edward Randall III Professor and Chairman, Professor) & Stanley G. Schultz M.D. (Professor and Chainnan) (Edward Randall III Professor and Chairman, Professor) &  (Professor and Chainnan)

  2. Department of Physiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Joseph F. Hoffman Ph.D. (Eugene Higgins Professor of Physiology) (Eugene Higgins Professor of Physiology)

  3. Division of Nephrology, University of California, 92093, San Diego, La Jolla, California, USA

    Darrell D. Fanestil M.D. (Professor of Medicine, Head) (Professor of Medicine, Head)

  4. Department of Internal Medicine, University of Texas Medical School, 77225, Houston, Texas, USA

    Thomas E. Andreoli M.D. (Edward Randall III Professor and Chairman, Professor) (Edward Randall III Professor and Chairman, Professor)

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© 1987 Plenum Publishing Corporation

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Rosenberg, H.C., Chiu, T.H., Putney, J.W., Askari, A. (1987). Modification of Membrane Function by Drugs. In: Andreoli, T.E., Hoffman, J.F., Fanestil, D.D., Schultz, S.G. (eds) Membrane Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1943-6_23

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  • DOI: https://doi.org/10.1007/978-1-4613-1943-6_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-42697-1

  • Online ISBN: 978-1-4613-1943-6

  • eBook Packages: Springer Book Archive

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