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Import of Cytochrome c1 and Cytochrome b2 into Mitochondria

  • J. Ostermann
  • F.-U. Hartl
  • M. Tropschug
  • B. Guiard
  • W. Neupert

Abstract

We have investigated the import pathways of the two mitochondrial proteins, cytochrome c1 (Neurospora crassa) and b2 (yeast). These proteins are synthesized in the cytosol as larger precursor molecules, posttranslationally imported into mitochondria and processed in two steps to their respective mature sized forms (1). Cytochrome c1 is a protein of the inner mitochondrial membrane with a large hydrophilic domain exposed to the intermembrane space. Cytochrome b2 is a soluble protein of the intermembrane space. Both proteins enter mitochondria via translocation contact sites (2).

Keywords

Mitochondrial Protein Mature Protein Import Pathway Neurospora Crassa Intermembrane Space 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. Ostermann
    • 1
  • F.-U. Hartl
    • 1
  • M. Tropschug
    • 1
  • B. Guiard
    • 1
    • 2
  • W. Neupert
    • 1
  1. 1.Institut für Physiologische ChemieUniversität MünchenDeutschland
  2. 2.Centre de Genetique MoleculaireGif-sur-YvetteFrance

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