Application of the Ohmeda Biox 3700 Pulse Oximeter to Neonatal Oxygen Monitoring

  • William W. HayJr.
  • Julia Brockway
  • Mario Eyzaguirre
Part of the Advances in Experimental Medicine and Biology book series (ABBI, volume 7)


Recently, pulse oximeters have been introduced into nurseries to monitor clinical blood oxygenation. Pulse oximeters measure the oxygen saturation of hemoglobin in pulsed (“arterial”) blood flow. Blood oxygen saturation provides a direct measure of blood oxygenation. However, this measure is variably related to the traditional measure of blood partial pressure of oxygen (PO2) and is affected by factors (e.g., hemoglobin concentration and hemoglobin-oxygen affinity) that may not alter PO2. Therefore, this discussion is written to review principles of blood oxygen transport and to demonstrate from data collected in newborn infants, relationships between pulse oxygen saturation (SpO2) blood oxygen saturation (SaO2) and blood PO2 in a variety of clinical conditions.


Pulse Oximeter Blood Oxygen Skin Blood Flow Pulse Saturation Blood Oxygen Saturation 
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  1. 1.
    Davenport, H. The ABC of Acid-Base Chemistry. Sixth Edition. University of Chicago Press, Chicago, 1974.Google Scholar
  2. 2.
    Benesch, R.E., Benesch, R. The Reaction Between Diphosphoglycerate and Hemoglobin. Fed. Proc. 29:1101–1104, 1970.Google Scholar
  3. 3.
    Orzalesi, M.M., Hay, W.W., Jr. The Relative Effects of 2,3-Diphosphoglycerate on the Oxygen Affinity of Fetal and Adult Hemoglobin in Whole Blood. Experimentia 28:1480–1481, 1972.CrossRefGoogle Scholar
  4. 4.
    Orzalesi, M.M., Hay, W.W., Jr. The Regulation of Oxygen Affinity of Fetal Blood. I. In Vitro Experiments and Results in Normal Infants. Pediatr. 48:857–864, 1971.Google Scholar
  5. 5.
    Meschia, G., Battaglia, F.C., Makowski, E.L., Droegenmueller, W. Effect of Varying Umbilical Blood O2 Affinity on Umbilical Vein PO2. J. Appl. Physiol. 26:410–416, 1969.Google Scholar
  6. 6.
    Oski, F. Clinical Implications of the Oxyhemoglobin Dissociation Curve in the Neonatal Period. Crit. Care Med. 7 (9):412–418, 1979.CrossRefGoogle Scholar
  7. 7.
    Delivoria-Papadopoulos, M., Roncevic, N.P., Oski, F.A. Postnatal Changes in Oxygen Transport of Term, Premature, and Sick Infants: The Role of Red Cell 2,3-Diphosphoglycerate and Adult Hemoglobin. Pediatr. Res. 5:235–245, 1971.CrossRefGoogle Scholar
  8. 8.
    Peeters, L.L.H., Sheldon, R.E., Jones, M.D., Jr., Makowski, E.L., Meschia, G. Blood Flow to Fetal Organs as a Function of Arterial Content. Am. J. Obstet. Gynecol. 135:637–646, 1979.Google Scholar
  9. 9.
    Sheldon, R., Peeters, L.L.H., Jones, M.D., Jr., Makowski, E.L., Meschia, G. Redistribution of Cardiac Output and Oxygen Delivery in the Hypoxemic Fetal Lamb. Am. J. Obstet. Gynecol. 135:1071–1078, 1979.Google Scholar
  10. 10.
    Fishman, A.P. Respiratory Gases in the Regulation of the Pulmonary Circulation. Physiol. Rev. 41–241, 1961.Google Scholar
  11. 11.
    Kinsey, V.E., Jacobus, J.T., Hemphill, F.M., et al. Cooperative Study of Retrolental Fibroplasia and the Use of Oxygen. Arch. Ophthalmol. 56:481–543, 1956.CrossRefGoogle Scholar
  12. 12.
    Lucey, J.F., Dangman, B. A reexamination of the Role of Oxygen in Retrolental Fibroplasia. Pediatr. 73:82–96, 1984.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • William W. HayJr.
    • 1
  • Julia Brockway
    • 1
  • Mario Eyzaguirre
    • 1
  1. 1.Department of PediatricsUniversity of Colorado Health Sciences CenterDenverUSA

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