Monoclonal Antibodies Reactive with the neu Oncogene Product Inhibit the Neoplastic Properties of neu-Transformed Cells
The past decade has seen major advances in our understanding of the molecular events involved in malignant transformation. Studies of RNA tumor viruses initially identified specific genes that were able to confer neoplastic properties on cells in tissue culture and that were responsible for tumor formation in vivo.(1) These genes were termed oncogenes. Subsequently, it was shown that genes closely related to retroviral oncogenes (protooncogenes) exist in the genomes of all eukaryotic cells. These protooncogenes have been highly conserved in evolution and are likely to play important roles in normal growth and development.(1,2) It is now clear that retroviruses have acquired their oncogenes by retroviral transduction of cellular protooncogenes. It is thought that elevated expression and/or structural alterations of protooncogenes within the retroviral genome are responsible for the abilities of some retroviruses to cause neoplastic transformation.
KeywordsEpidermal Growth Factor Receptor Ascites Fluid Specific Lysis Cellular Oncogene erbB Oncogene
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