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SV40 Tumor Antigen

Importance of Cell Surface Localization in Transformation and Immunological Control of Neoplasia

  • Chapter
Development and Recognition of the Transformed Cell

Abstract

The concept of immunosurveillance is nowhere as readily demonstrated as in the SV40 tumor system. The age-related resistance to tumor induction by SV40, abrogation of that resistance by thymectomy and x irradiation, immunological intervention during the latent period resulting in the abrogation of virus carcinogenesis, high rate of spontaneous regression of primary SV40 tumors in the host, prevention of SV40 tumor transplantation in the preimmunized host, and involvement of thymus derived lymphocytes in the immunologically mediated rejection of SV40 tumor cells are all indicative of the fact that SV40-tranformed cells derived either SV40-induced tumors or, transformed in vitro, possess strong antigens at the cell surface. In this article, we will review the nature and viral origin of the transplantation rejection antigen and will discuss evidence that the protein involved in the initiation and maintenance of transformation by SV40 tumor or T antigen also provides a target for the cellular immune response by virtue of its location at the surface of SV40-transformed cells.

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Authors and Affiliations

  1. Department of Microbiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, 17033, USA

    Satvir S. Tevethia

  2. Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas, 77030, USA

    Janet S. Butel

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  1. Satvir S. Tevethia
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  2. Janet S. Butel
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Editors and Affiliations

  1. Division of Immunology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104-6082, USA

    Mark I. Greene

  2. Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, Osaka, 553, Japan

    Toshiyuki Hamaoka

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© 1987 Plenum Press, New York

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Tevethia, S.S., Butel, J.S. (1987). SV40 Tumor Antigen. In: Greene, M.I., Hamaoka, T. (eds) Development and Recognition of the Transformed Cell. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1925-2_15

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  • DOI: https://doi.org/10.1007/978-1-4613-1925-2_15

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