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Cell-to-Cell Communication pp 187–222Cite as

Cell Communication and Growth

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Abstract

The possibility that gap junctions play an important role in the control of cell proliferation (Furshpan and Potter, 1968; Loewenstein, 1968) has probably stimulated more interest and generated more controversy than any of their other suggested functions. Much of the attention given this idea has in fact been elicited by the corollary notion that defects in the junctions may contribute to the aberrant control of cell division in cancer (Loewenstein, 1968). Numerous comprehensive reviews, appearing in the last several years, have summarized the rather checkered history of these two related ideas (e.g., Loewenstein, 1979, 1981; Trosko et al., 1983; Sheridan and Atkinson, 1985; Vitkauskas and Canellakis, 1985). Rather than take a similar, and arguably redundant, approach, this chapter will focus on underlying concepts, using several more recent and selected research findings from various laboratories as illustrative examples.

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  1. Department of Cell Biology and Neuroanatomy, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA

    Judson D. Sheridan

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  1. Department of Pharmacology, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico, 00936

    Walmor C. De Mello

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© 1987 Plenum Press, New York

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Sheridan, J.D. (1987). Cell Communication and Growth. In: De Mello, W.C. (eds) Cell-to-Cell Communication. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1917-7_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1917-7_6

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