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Long-Term Results of Transsphenoidal Surgery for the Management of Acromegaly

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Acromegaly

Abstract

Although acromegaly as a medical entity was described as early as 1779, it was 100 years ago in 1886 that the French neurologist Pierre Marie (1) coined the term, acromegaly, and presented the clinical details of two cases. Considerable interest in acromegaly rapidly evolved, but the pathophysiology and etiology of the disorder was not at all clear to the initial investigators. Minkowski in 1887 and subsequently Marie and Marinesco (2) all noted that enlargement of the pituitary was a constant feature in autopsied cases of acromegaly, but this was thought by some to be merely part of a generalized process resulting in hypertrophy of various glands. By 1900 pathophysiologic correlations suggested an etiologic role for pituitary hypertrophy or neoplasia, and Dean Lewis in 1905 (3) propagated the concept among the surgical community.

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Author information

Authors and Affiliations

  1. Mayo Clinic, Rochester, MN, USA

    Edward R. Laws Jr. M.D., Sandra M. Carpenter R.N., Bernd W. Scheithauer M.D. & Raymond V. Randall M.D.

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  1. Edward R. Laws Jr. M.D.
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  2. Sandra M. Carpenter R.N.
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  3. Bernd W. Scheithauer M.D.
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  4. Raymond V. Randall M.D.
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Editor information

Editors and Affiliations

  1. Yale University, New Haven, Connecticut, USA

    Richard J. Robbins M.D. (Co-Chairman) (Co-Chairman)

  2. Cedars Sinai Medical Center, UCLA School of Medical Science, Los Angeles, California, USA

    Shlomo Melmed M.D. (Co-Chairman) (Co-Chairman)

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© 1987 Plenum Press, New York

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Laws, E.R., Carpenter, S.M., Scheithauer, B.W., Randall, R.V. (1987). Long-Term Results of Transsphenoidal Surgery for the Management of Acromegaly. In: Robbins, R.J., Melmed, S. (eds) Acromegaly. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1913-9_24

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  • DOI: https://doi.org/10.1007/978-1-4613-1913-9_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9064-3

  • Online ISBN: 978-1-4613-1913-9

  • eBook Packages: Springer Book Archive

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