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Noncholinergic Mechanisms Involved in the Behavioral and Stimulus Effects of Nicotine, And Relationships to the Process of Nicotine Dependence

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Tobacco Smoking and Nicotine

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 31))

Abstract

A major objective of research conducted by this investigator over the last 18 years has been to evaluate the pharmacological mechanisms by which nicotine can alter behavior, and the role that such mechanisms may have in the process of nicotine-induced dependence. The overall goals of this research have been to: (1) determine potential brain area sites of nicotine action important to its pharmacological effects; (2) determine whether nicotine is acting at cholinergic receptors (pre-or postsynaptic) excited (or inhibited) by the neurotransmitter acetylcholine (ACh); and (3) to determine the potential role that noncholinergic neurons play in the CNS pharmacology of nicotine. The overall approaches utilized in this research evolved from earlier research conducted by Domino (1) in which he very clearly showed that brain cholinergic neurons were not interdependent, as in the periphery, but existed as two independent receptor populations, muscarinic (M-Cholinergic; M-Ch) and nicotinic (N-Cholinergic; N-Ch).

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology School of Basic Health Sciences, Virginia Commonwealth University, Richmond, VA, 23298, USA

    John A. Rosecrans

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  1. John A. Rosecrans
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Kentucky, Lexington, Kentucky, 40536, USA

    William R. Martin

  2. Department of Medicine, Veterans Administration Medical Center University of Kentucky, Lexington, Kentucky, 40511, USA

    Glen R. Van Loon

  3. Department of Pharmacology College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  4. The Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  5. Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 04546-0236, USA

    Layten Davis (Director) (Director)

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© 1987 Plenum Press, New York

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Rosecrans, J.A. (1987). Noncholinergic Mechanisms Involved in the Behavioral and Stimulus Effects of Nicotine, And Relationships to the Process of Nicotine Dependence. In: Martin, W.R., Van Loon, G.R., Iwamoto, E.T., Davis, L. (eds) Tobacco Smoking and Nicotine. Advances in Behavioral Biology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1911-5_9

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  • DOI: https://doi.org/10.1007/978-1-4613-1911-5_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9063-6

  • Online ISBN: 978-1-4613-1911-5

  • eBook Packages: Springer Book Archive

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