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InVitro and InVivo Biomethylation of Nicotine Enantiomers

  • C. Steven Godin
  • William F. Pool
  • Chukwuemeka G. Nwosu
  • Peter A. Crooks
Part of the Advances in Behavioral Biology book series (ABBI, volume 31)

Abstract

Both S-(-)-nicotine and R-(+)-nicotine are reported to be constituents of tobacco smoke condensate. Although numerous studies have been published on the metabolic fate of the S-(-)-enantiomer, little is known about the biotransformation of the unnatural R-(+)-isomer. In this study, the comparative metabolic fates of both optical isomers of nicotine are examined.

Keywords

Metabolic Fate Urinary Metabolite Optical Isomer Crude Enzyme Preparation Intravenous Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • C. Steven Godin
    • 1
  • William F. Pool
    • 1
  • Chukwuemeka G. Nwosu
    • 1
  • Peter A. Crooks
    • 1
  1. 1.College of Pharmacy and Graduate Center for ToxicologyUniversity of KentuckyLexingtonUSA

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