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Dose-Related Nicotine Effects on CNS Binding and Behavior

  • Charles Ksir
  • Robert L. Hakan
  • Kenneth J. Kellar
Part of the Advances in Behavioral Biology book series (ABBI, volume 31)

Abstract

Repeated nicotine exposures increase both central nicotinic receptor numbers and the behavioral stimulant effect of nicotine. In the present experiments, the behavioral effects of graded doses of nicotine (0.1 to 1.6 mg/kg, s.c.) were observed in photocell activity cages both before and after the rats were given five daily injections of 0.2 mg/kg nicotine in their home cages. Comparing the behavioral response after five days of exposure to the response prior to exposure revealed an upward shift in the dose-response curve (Fig. 1).

Keywords

Inferior Colliculus Nicotine Exposure Nicotine Administration Retrosplenial Cortex Stratum Oriens 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Charles Ksir
    • 1
  • Robert L. Hakan
    • 1
  • Kenneth J. Kellar
    • 2
  1. 1.University of WyomingUSA
  2. 2.Georgetown UniversityUSA

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