Nicotinic and Muscarinic Regulation of Adrenal Catecholamine Secretion
The adrenal medulla has served as a very useful experimental tool to investigate a wide variety of noradrenergic mechanisms. The adrenal medulla is innervated by splanchnic neurons originating in the spinal cord, and about three synaptic contacts are made by splanchnic nerve endings on one chromaffin cell (1). Splanchnic neurons have been regarded as predominantly cholinergic in nature and contain acetylcholine as a principal neurotransmitter (2). The well-known sequence of events is that an increase in the activity of presynaptic splanchnic nerves causes the release of acetylcholine which, in turn, activates postsynaptic cholinergic receptors to trigger the secretion of medullary hormones.
KeywordsAdrenal Gland Muscarine Receptor Chromaffin Cell Phorbol Ester Adrenal Medulla
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