The Influence of Subinhibitory Concentrations of Antibiotics on the Bacterial Surface with Respect to Host Defense Mechanisms
It is well known that a successful treatment of bacterial infections depends on an effective host defense system. This observation presupposes either that the antibiotic treatment reduces the number of bacteria in a given infection and that the remaining bacteria are subsequently eliminated by the host-defense system, or that antibiotics render bacteria more susceptible to host defense mechanisms. In addition, it is well established that β-lactam antibiotics interfere with peptidoglycan synthesis and that this is combined with changes in the shape of bacteria. Several authors (2,3,12) have pointed out that there is a mutual influence between peptidoglycan and membrane synthesis, but the arrangement and composition of the outer membrane under the influence of (β-lactam antibiotics have so far not been investigated adequately.
KeywordsOuter Membrane Outer Membrane Protein Proteus Mirabilis Buoyant Density Subinhibitory Concentration
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- 10.B. B. Mishell and S. M. Shigii, eds., “Selected Methods in Cellular Immunology,” Freeman, San Francisco (1980).Google Scholar
- 11.S. Muller, F. Falkenberg, R. A. Fromtling, A. M. Fromtling and V. Klimetzek, Signals of chemiluminescence emitted by spleen cells and bone marrow macrophages after stimulation with mitogens and particulate substances, in: “Bioluminescence and Chemiluminescence,” M. A. de Luca and W. D. McElroy, eds., Academic Press, New York (1981).Google Scholar
- 12.H. J. Rogers and P. F. Thurman, Interrelationships between wall and membrane synthesis, in: “The Target of Penicillin,” R. Hackenbeck, J. V. Holtje and H. Labischinski, eds., Walter de Gruyter, Berlin, New York (1983).Google Scholar
- 14.S. Schlecht and O. Westphal, Uber die Herstellung von Antiseren gegen somatische (O-) Antigene von Salmonellen. II. Mitteilung: Untersuchungen uber Hamagglutinintiter, Zbl. Bakt. Hyg. Abt. I, Orig. 205:487 (1967).Google Scholar