Advertisement

Antibodies pp 81-89 | Cite as

Induction of Antibodies to Pseudorabies Virus by Immunization with Anti-Idiotypic Antibodies

  • Michael F. Gurish
  • Tamar Ben-Porat
  • Alfred Nisonoff

Abstract

In 1974, Niels Jerne (10) proposed that an anti-idiotypic antibody (anti-anti-X) might sometimes express an “internal image” of X; i.e., that the combining region of the anti-idiotypic (anti-Id) antibody could have structural features in common with antigen X (This is consistent with the fact that both can interact with anti-X.) We have suggested the term “related epitope” or anti-Id(RE) to describe the feature held in common by the two substances (19). This term intentionally suggests that the structural relationship might be confined to a single epitope and that the epitopes on X and on anti-anti-X might be serologically cross-reactive but not necessarily identical. Until 1978, Jerne’s postulate represented an interesting hypothesis but did not have experimental support. In that year, Sege and Peterson (26) made two observations that are most readily interpreted on the basis of the internal image concept. They prepared antibodies to insulin in rats and affininty-purified them. Anti-Id antibodies were next elicited in rabbits against the purified rat anti-insulin, and adsorbed in the usual way to remove antibodies to non-idiotypic determinants. The absence of anti-insulin was ensured by passage over an insulin-containing column. These anti-Id antibodies mimicked the behavior of insulin in two ways: they inhibited the binding of radiolabeled insulin to rat epididymal fat cells and they stimulated the uptake of α-aminoisobutyric acid by rat thymocytes.

Keywords

Schistosoma Mansoni Pseudorabies Virus Internal Image Related Epitope Mammalian Reovirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    W. L. Cleveland, N. H. Wassermann, R. Sarangarajan, A. S. Penn, and B. F. Erlanger, Monoclonal antibodies to the acetylcholine receptor by a normally functioning auto-anti-idiotypic mechanism, Nature 305: 56 (1983)PubMedCrossRefGoogle Scholar
  2. 2.
    M. S. Co, G. N. Gaulton, K. K. McDade, B. N. Fields, and M. I. Greene, Isolation and biochemical characterization of the mammalian reovirus type 3 cell-surface receptor, J. Exp. Med. 160: 1195 (1984).CrossRefGoogle Scholar
  3. 3.
    H.C.J. Ertl and R. W. Finberg, Sendai virus-specific T cell clones: Induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T cell clone, Proc. Natl. Acad. Sci. U.S.A. 81: 2850 (1984)PubMedCrossRefGoogle Scholar
  4. 4.
    H.C.J. Ertl, E. Homas, S. Tournas, and R. W. Finberg, Sendai virus-specific T cell clones. V. Induction of a virus specific response by anti-idiotypic antibodies directed against a T helper cell clone, J. Exp. Med. 159: 1778 (1984).CrossRefGoogle Scholar
  5. 5.
    N. R. Farid, R. Briones-Urbina, and M. Nazrul-Islam, Biologic activity of anti-thyrotropin anti-idiotypic antibody, J. Cell. Biochem. 19: 305 (1982).PubMedCrossRefGoogle Scholar
  6. 6.
    P.G.H. Gell and P.A.H. Moss, Production of cell-mediated immune response to herpes simplex by immunization with anti-idiotypic hetero-antisera, J. Gen. Virol. 66: 1801 (1985).PubMedCrossRefGoogle Scholar
  7. 7.
    J. M. Grzych, M. Capron, P. H. Lambert, C. Dissous, S. Torres, and A. Capron, An anti-idiotypic vaccine against experimental schistosomiasis, Nature 316: 74 (1985).PubMedCrossRefGoogle Scholar
  8. 8.
    H. Hampl, T. Ben-Porat, L. Ehrlicher, K. Habermehl, and A. S. Kaplan, Characterization of the envelope proteins of pseudorabies virus, J. Virol. 52: 583 (1984).PubMedGoogle Scholar
  9. 9.
    C. J. Homey, S. G. Rockson, and E. Haber, An anti-idiotypic antibody that recognizes the beta-adrenergic receptor, J. Clin. Invest. 69: 1147 (1982).CrossRefGoogle Scholar
  10. 10.
    N. K. Jerne, Towards a network theory of the immune system, Ann. Immunol. 125C: 373 (1974).Google Scholar
  11. 11.
    R. S. Kauffman, J. H. Noseworthy, J. T. Nepom, R. Finberg, B. N. Fields, and M. I. Greene, Cell receptors for mammalian reovirus II. Monoclonal anti-idiotypic antibody blocks viral binding to cells, J. Immunol. 131: 2539 (1983).PubMedGoogle Scholar
  12. 12.
    S.H.E. Kaufmann, K. Eichmann, I. Muller, and L. J. Wrazel, Vaccination against the intracellular becterium Listeria monocytogenes with a clonotypic antiserum, J. Immunol. 134: 4123 (1985).PubMedGoogle Scholar
  13. 13.
    R. C. Kennedy, K. Adker-Storthz, R. D. Henkel, Y. Sanchez, J. L. Melnick, and G. R. Dreesman, Immune response to hepatitis B surface antigen: enhancement by prior injection of antibodies to the idiotype, Science 221: 853 (1983).PubMedCrossRefGoogle Scholar
  14. 14.
    R. C. Kennedy and G. R. Dreesman, Enhancement of the immune response to hepatitis B surface antigen: in vivo administration of anti-idiotype induced anti-HBs that expresses a similar idiotype, J. Exp. Med. 159: 655 (1984).PubMedCrossRefGoogle Scholar
  15. 15.
    R. C. Kennedy, I. Ionescu-Matiu, Y. Sanchez, and G. R. Dreesman, Detection of interspecies idiotypic cross-reactions associated with anti¬bodies to hepatitis B surface antigen, Eur. Immunol. 13: 232 (1983).CrossRefGoogle Scholar
  16. 16.
    R. C. Kennedy, J. L. Melnick, and G. R. Dreesman, Antibody to hepatitis B virus induced by injecting antibodies to the idiotype, Science 223: 930 (1984).PubMedCrossRefGoogle Scholar
  17. 17.
    M. K. McNamara, R. E. Ward, and H. Kohler, Monoclonal idiotype vaccine against Streptococcus pneumoniae infection, Science 226: 1325 (1984).PubMedCrossRefGoogle Scholar
  18. 18.
    W. A. Marasco and E. L. Becker, Anti-idiotype as antibody against the formyl peptide chemotaxis receptor of the neutrophil, J. Immunol. 128: 963 (1982).PubMedGoogle Scholar
  19. 19.
    A. Nisonoff and E. Lamoyi, Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: possible application to vaccine production, Clin. Immunol. Immunopathol. 21: 397 (1981).CrossRefGoogle Scholar
  20. 20.
    J. H. Noseworthy, B. N. Fields, M. A. Dichter, C. Sobotka, E. Pizer, L. L. Perry, J. T. Nepom, and M. I. Green, Cell receptors for mammalian reovirus I. Syngeneic monoclonal anti-idiotypic antibody identifies a cell surface receptor for reovirus, J. Immunol. 131: 2533 (1983).PubMedGoogle Scholar
  21. 21.
    J. Oudin and M. Michel, Une nouvelle forme d’allotypie des globulins du sérum du lapin, apparement lieé a la fonction et a la spécificité anticorps, C.R. Acad. Sci. (Paris) 257: 805 (1963).Google Scholar
  22. 22.
    K. J. Reagan, W. H. Wunner, T. J. Wiktor, and H. Koprowski, Anti-idio- typic antibodies induce neutralizing antibodies to rabies virus glycoprotein, J. Virology 48: 660 (1983).PubMedGoogle Scholar
  23. 23.
    I. M. Roitt, D. K. Male, G. Guarnotta, L. P. de Carvalho, A. Cooke, F. C. Hay, P. M. Lydyard, Y. Thanavala, and J. Ivanyi, Idiotypic networks and their possible exploitation for manipulation of the immune response, Lancet 1: 1041 (1981).PubMedCrossRefGoogle Scholar
  24. 24.
    D. L. Sacks, K. M. Esser, and A. Sher, Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies, J. Exp. Med. 155: 1108 (1982).PubMedCrossRefGoogle Scholar
  25. 25.
    A. B. Schreiber, P. O. Couraud, C. Andre, B. Vray, and A. D. Strosberg, Anti-alprenolol anti-idiotypic antibodies bind to beta-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase, Proc. Natl. Acad. Sci. U.S.A. 77: 7385 (1980).PubMedCrossRefGoogle Scholar
  26. 26.
    K. Sege and P. A. Peterson, Use of anti-idiotypic antibodies as cell surface receptor probes, Proc. Natl. Acad. Sci. U.S.A. 75: 2443 (1978).PubMedCrossRefGoogle Scholar
  27. 27.
    A. H. Sharpe, G. N. Gaulton, K. K. McDade, B. N. Fields, and M. I. Greene, Syngenic monoclonal anti-idiotype can induce cellular immunity to reovirus, J. Exp. Med. 160: 1195 (1984).PubMedCrossRefGoogle Scholar
  28. 28.
    K. E. Stein and T. Soderstrom, Neonatal administration of idiotype or anti-idiotype primes for protection against Escherichia coli K13 infection in mice, J. Exp. Med. 100: 1001 (1984).CrossRefGoogle Scholar
  29. 29.
    A. S. Tung, S. Sato, and A. Nisonoff, Production of large amounts of antibodies in individual mice, J. Immunol. 116: 676 (1976).PubMedGoogle Scholar
  30. 30.
    F.G.C.M. Uytdehaag and A.D.M.E. Osterhaus, Induction of neutralizing antibody in mice against Poliovirus type II with monoclonal anti-idiotypic antibody, J. Immunol. 134: 1225 (1985).PubMedGoogle Scholar
  31. 31.
    N. H. Wasserman, A. S. Penn, P. I. Freimuth, N. Treptow, S. Wentzel, W. L. Cleveland, and B. F. Erlanger, Anti-idiotypic route to anti-acetylcholine receptor antibodies and experimental myasthenia gravis, Proc. Natl. Acad. Sci. U.S.A. 79: 4810 (1982).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Michael F. Gurish
    • 1
  • Tamar Ben-Porat
    • 2
  • Alfred Nisonoff
    • 1
  1. 1.Department of BiologyRosenstiel Research Center Brandeis UniversityWalthamUSA
  2. 2.Department of MicrobiologySchool of Medicine Vanderbilt UniversityNashvilleUSA

Personalised recommendations