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Functional Maturation of B Cell Repertoire Expression

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Book cover Antibodies

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Abstract

The adult murine primary B cell repertoire is extremely diverse with estimates suggesting that it is comprised of more than 107 distinct specificities (4,19,27,30,39). The recognition and specificity of any B cell and its antibody product is determined by the different heavy and light chain gene segments that are selected for rearrangement and expression in that cell. The final mature B cell repertoire of an animal, therefore, is a result of the genetic V region potential of that animal, processes which select from within that genetic potential and environmental influences on the B cells expressing the genetic potential. The extent to which each of these factors functions during the maturation of the B cell repertoire must be evaluated to understand how the immune system of an animal expresses an effective and non-self-detrimental repertoire of B cell recognition specificities.

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Authors and Affiliations

  1. Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California, USA

    Barbara G. Froscher & Norman R. Klinman

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  1. Barbara G. Froscher
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  2. Norman R. Klinman
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Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Unversity of South Florida, Tampa, Florida, USA

    Andor Szentivanyi M.D. (Dean of the College of Medicine, Deputy Vice President for Medical Affairs, Chairman and Professor) (Dean of the College of Medicine, Deputy Vice President for Medical Affairs, Chairman and Professor)

  2. Department of Biochemistry, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Paul H. Maurer Ph.D. (Chairman and Professor) (Chairman and Professor)

  3. Immunology, Allergic and Immunologic Diseases Program National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA

    Bernard W. Janicki Ph.D. (Deputy Director) (Deputy Director)

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© 1987 Plenum Press, New York

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Froscher, B.G., Klinman, N.R. (1987). Functional Maturation of B Cell Repertoire Expression. In: Szentivanyi, A., Maurer, P.H., Janicki, B.W. (eds) Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1873-6_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1873-6_6

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