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Antibodies pp 189–200Cite as

Monoclonal Antibodies and Immunoconjugates as Anti-Cancer Agents

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Abstract

The use of antibodies in the treatment of human solid tumors is supported by sufficient preclinical and clinical data to suggest that this approach will be of real value in the development of selective biotherapy (1). Most of the early antibody trials focused on the use of unconjugated antibody to determine toxicity, tolerance, the localization in solid tumor deposits. These studies defined the distribution of antibody in normal and neoplastic tissues (2–8).

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Author information

Authors and Affiliations

  1. Biological Therapy Institute, Franklin, Tennessee, USA

    Robert K. Oldham

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  1. Robert K. Oldham
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Unversity of South Florida, Tampa, Florida, USA

    Andor Szentivanyi M.D. (Dean of the College of Medicine, Deputy Vice President for Medical Affairs, Chairman and Professor) (Dean of the College of Medicine, Deputy Vice President for Medical Affairs, Chairman and Professor)

  2. Department of Biochemistry, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Paul H. Maurer Ph.D. (Chairman and Professor) (Chairman and Professor)

  3. Immunology, Allergic and Immunologic Diseases Program National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA

    Bernard W. Janicki Ph.D. (Deputy Director) (Deputy Director)

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© 1987 Plenum Press, New York

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Oldham, R.K. (1987). Monoclonal Antibodies and Immunoconjugates as Anti-Cancer Agents. In: Szentivanyi, A., Maurer, P.H., Janicki, B.W. (eds) Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1873-6_16

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  • DOI: https://doi.org/10.1007/978-1-4613-1873-6_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9044-5

  • Online ISBN: 978-1-4613-1873-6

  • eBook Packages: Springer Book Archive

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