Retrotransposition in Yeast
The Ty elements of yeast are repetitive chromosomal elements capable of transposition, a nonhomologous recombination event that leads to insertion of an element at a new chromosomal site. The structure of Ty elements is similar to that of the endogenous proviruses found in vertebrates (Clare and Farabaugh, 1985; Mount and Rubin, 1985). Each element contains a large central portion of approximately 5.2 kilobases flanked by direct repeats of about 330 base pairs (bp) called 5 or long terminal repeat (LTR) sequences (Fig. 1). Ty elements are repeated about 30–40 times per haploid genome and are found in variable chromosomal locations in different strains.
KeywordsRecombination Catalysis Sarcoma Resi Tryptophan
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