Abstract
Cells respond to a sudden increase in temperature by increasing their rate of synthesis of a small number of proteins (reviewed in Neidhardt et al., 1984; Schlesinger et al., 1982). This response is called the heat-shock response, and the proteins synthesized in response to heat stress are called the heat-shock proteins (HSPs). Both prokaryotes and eukaryotes have been shown to have a heat-shock response (Schlesinger et al., 1982). At least two of the HSPs are strongly conserved between prokaryotes and eukaryotes (Bardwell and Craig, 1984), suggesting that the response serves a similar function in all organisms.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baker, T. A., Grossman, A. D., and Gross, C. A., 1984, A gene regulating the heat shock response in Escherichia coli also affects proteolysis, Proc. Natl. Acad. Sci. U.S.A. 81:6779–6783.
Bardwell, J. C. A., and Craig, E. A., 1984, Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous, Proc. Natl. Acad. Sci. U.S.A. 81:848–852.
Bukhari, A. I., and Zipser, D., 1973, Mutants of Escherichia coli with a defect in the degradation of nonsense fragments, Nature New Biol. 243:238–241.
Charette, M. F., Henderson, G. W., and Markovitz, A., 1981, ATP hydrolysis-dependent protease activity of the Ion (capR) protein of Escherichia coli K12, Proc. Natl. Acad. Sci. U.S.A. 78:4728–4732.
Chung, C. H., and Goldberg, A. L., 1981, The product of the Ion (capR) gene in Escherichia coli is the ATP-dependent protease, protease La, Proc. Natl. Acad. Sci. U.S.A. 78:4931–4935.
Cowing, D. W., Bardwell, J. C. A., Craig, E. A., Woolford, C., Hendrix, R. W., and Gross, C. A., 1985, Consensus sequence for Escherichia coli heat shock gene promoters, Proc. Natl. Acad. Sci. U.S.A. 82:2679–2683.
Drahos, D. J., and Hendrix, R. W., 1982, Effect of bacteriophage lambda infection on the synthesis of groE protein and other Escherichia coli proteins, J. Bacteriol. 149:1050–1063.
Finley, D., Ciechanover, A., and Varshavsky, A., 1984, Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85, Cell 37:43–55.
Goff, S. A., and Goldberg, A. L., 1985, Production of abnormal proteins in E. coli stimulates transcription of Ion and other heat shock genes, Cell 41:587–595.
Goff, S. A., Casson, L. P., and Goldberg, A. L., 1984, The heat shock regulatory gene, htpR ,influences rates of protein degradation and expression of the Ion gene in Escherichia coli, Proc. Natl. Acad. Sci. U.S.A. 81:6647–6651.
Goldberg, A. L., 1972, Degradation of abnormal proteins in Escherichia coli, Proc. Natl. Acad. Sci. U.S.A. 69:422–426.
Gottesman, S., and Zipser, D., 1978, Deg phenotype of Escherichia coli lon mutants, J. Bacteriol. 133:844–851.
Gross, C. A., Grossman, A. D., Liebke, H., Walter, W., and Burgess, R. R., 1984, Effects of the mutant sigma allele rpoD800 on the synthesis of specific macromolecular components of the Escherichia coli K-12 cell, J. Mol. Biol. 172:283–300.
Grossman, A. D., Erickson, J. W., and Gross, C. A., 1984, The htpR gene product of E. coli is a sigma factor for heat shock promoters, Cell 38:383–390.
Grossman, A. D., Taylor, W. E., Burton, Z. F., Burgess, R. R., and Gross, C. A., 1985, Stringent response in Escherichia coli induces expression of heat shock proteins, J. Mol. Biol. 186:357–365.
Kochan, J., and Murialdo, H., 1982, Stimulation of groE synthesis in Escherichia coli by bacteriophage lambda infection, J. Bacteriol. 149:1166–1170.
Krueger, J. H., and Walker, G., 1984, groEL and dnaK genes of Escherichia coli are induced by UV irradiation and nalidixic acid in an htpR+-dependent fashion, Proc. Natl. Acad. Sci. U.S.A. 81:1499–1503.
Landick, R., Vaughn, V., Lau, E. T., VanBogelen, R. A., Erickson, J. W., and Neid-hardt, F. C., 1984, Nucleotide sequence of the heat shock regulatory gene of E. coli suggests its protein product may be a transcription factor, Cell 38:175–182.
Lemaux, P. G., Herendeen, S. L., Bloch, P. L., and Neidhardt, F. C., 1978, Transient rates of synthesis of individual polypeptides in E. coli following temperature shifts, Cell 13:427–434.
Neidhardt, F. C., and VanBogelen, R. A., 1981, Positive regulatory gene for temperature-controlled proteins in Escherichia coli, Biochem. Biophys. Res. Commun. 100:894–900.
Neidhardt, F. C., VanBogelen, R. A., and Vaughn, V., 1984, The genetics and regulation of heat shock proteins, Annu. Rev. Genet. 18: 295–329.
Phillips, T. A., VanBogelen, R. A., and Neidhardt, F. C., 1984, lon gene product of Escherichia coli is a heat-shock protein, J. Bacteriol. 159:283–287.
Schlesinger, M. J., Ashburner, M., and Tissieres, A. (eds.), 1982, Heat Shock from Bacteria to Man ,Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Taylor, W. E., Straus, D. B., Grossman, A. D., Burton, Z. F., Gross, C. A., and Burgess, R. R., 1984, Transcription from a heat-inducible promoter causes heat shock regulation of the sigma subunit of E. coli RNA polymerase, Cell 38:371–381.
Tilly, K., McKittrick, N., Zylicz, M., and Georgopoulos, C., 1983, The dnaK protein modulates the heat-shock response of Escherichia coli, Cell 34:641–646.
Tobe, T., Ito, K., and Yura, T., 1984, Isolation and physical mapping of temperature-sensitive mutants defective in heat-shock induction of proteins in Escherichia coli ,Mol. Gen. Genet. 195:10–16.
Yamamori, T., and Yura, T., 1980, Temperature-induced synthesis of specific proteins in Escherichia coli: Evidence for transcriptional control, J. Bacteriol. 142:843–851.
Yamamori, T., and Yura, T., 1982, Genetic control of heat-shock protein synthesis and its bearing on growth and thermal resistance in Escherichia coli K12, Proc. Natl. Acad. Sci. U.S.A. 79:860–864.
Yura, T., Tobe, T., Ito, K., and Osawa, T., 1984, Heat-shock regulatory gene (htpR) of Escherichia coli is required for growth at high temperature but is dispensable at low temperature, Proc. Natl. Acad. Sci. U.S.A. 81:6803–6807.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Gross, C. et al. (1987). Regulation of the Heat-Shock Response in Escherichia coli. In: Poste, G., Crooke, S.T. (eds) New Frontiers in the Study of Gene Functions. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1845-3_2
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1845-3_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9030-8
Online ISBN: 978-1-4613-1845-3
eBook Packages: Springer Book Archive