Abstract
The different functional classes of T lymphocytes recognize antigen on the surface of distinct populations of target cells. Helper T cells interact largely with macrophages and B cells; cytotoxic T cells interact with a broader range of antigen-bearing target cells. These cellular recognition events are likely to be mediated by the specific association of surface molecules on both effector and target cells. The surface of T cells is characterized by a number of polymorphic, as well as nonpolymorphic, proteins that are restricted for the most part to T lymphocytes. Although most of these molecules are common to all T cells, two classes of surface proteins consistently differ on the different functional classes of mature T lymphocytes: the T-cell antigen receptor and the surface glycoproteins T4 and T8. These proteins have therefore been implicated in T cell-target cell interactions.
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Dalgleish, A.G. et al. (1987). T4: A T-Cell Surface Protein Mediating Cell-Cell and Cell-AIDS Virus Interactions. In: Poste, G., Crooke, S.T. (eds) New Frontiers in the Study of Gene Functions. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1845-3_13
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DOI: https://doi.org/10.1007/978-1-4613-1845-3_13
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