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Formulation and Properties of an Alcohol-Free, Pharmaceutical Microemulsion System

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Book cover Surfactants in Solution

Abstract

An alcohol-free, water-in-oil microemulsion was formulated using two high molecular weight, pharmaceutically acceptable surfactants: sorbitan monolaurate (Arlacel 20 or Span 20) and sodium dioctyl sulfosuccinate (AOT). The amount of water solubilized depended on the oil chain length, the relative amounts of the two surfactants and the salinity of the water as well as the total surfactant weight. The optimal system contained equal weights of AOT and Arlacel 20 in hexadecane. With this system, one can obtain an isotropic dispersion containing equal volumes of oil and water with 21% total surfactants and no alcohol. With AOT and Arlacel 20 at a 1:1 weight ratio in hexadecane, the molecular ratio of water to total surfactant present was approximately 50. Addition of electrolytes drastically reduced water solubilization in the microemulsion system. Maximum water solubilization corresponded to a low interfacial tension between the oil and water. For a given oil chain length, a specific molar ratio of AOT to Arlacel 20 was required for maximum solubilization of water in the oil. Since the emulsifiers used are pharmaceutically acceptable, this microemulsion is promising for pharmaceutical and cosmetic applications.

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Author information

Authors and Affiliations

  1. Center for Surface Science and Engineering, University of Florida, Gainesville, Florida, 32611, USA

    K. A. Johnson & D. O. Shah

Authors
  1. K. A. Johnson
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  2. D. O. Shah
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Editor information

Editors and Affiliations

  1. IBM Corporate Technical Institutes, 500 Columbus Ave., Thornwood, NY, 10594, USA

    Kashmiri Lal Mittal M.Sc.(First Class First), Ph.D. (Fellow of the American Institute of Chemists and Indian Chemial Society) (Fellow of the American Institute of Chemists and Indian Chemial Society)

  2. Centre de Recherches Paul Pascal, Domaine Universitaire, F-33405, Talence Cedex, France

    P. Bothorel (Professor of Chemistry at the University of Bordeaux, Assistant Director, Scientific Director of the GRECO “Microemulsions” (French cooperative action on microemulsions), consultant to the French Oil Company) (Professor of Chemistry at the University of Bordeaux, Assistant Director, Scientific Director of the GRECO “Microemulsions” (French cooperative action on microemulsions), consultant to the French Oil Company)

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© 1986 Plenum Press, New York

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Johnson, K.A., Shah, D.O. (1986). Formulation and Properties of an Alcohol-Free, Pharmaceutical Microemulsion System. In: Mittal, K.L., Bothorel, P. (eds) Surfactants in Solution. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1833-0_26

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  • DOI: https://doi.org/10.1007/978-1-4613-1833-0_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9024-7

  • Online ISBN: 978-1-4613-1833-0

  • eBook Packages: Springer Book Archive

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