Fibrinogen/Platelet Interaction with PGI2 Analog-Heparin Immobilized Albuminated Polyurethane

  • C. P. Sharma
  • George Joseph
Chapter

Abstract

Fibrinogen adsorption and platelet adhesion studies were done on modified polyetherurethane urea vascular grafts fabricated by precipitation method on clean glass rods. Surface modification was done by immobilizing heparin and PGI2 analog on albuminated polymer substrate. The results indicated that although these biologically modified surfaces adsorbed more fibrinogen, the platelet adherence was less. Therefore the antiplatelet activity of the immobilized biomolecules should also be given attention while interpreting the fibrinogen-platelet interrelationship towards thrombogenicity.

Keywords

Albumin Urea Citrate Heparin Dimethyl 

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • C. P. Sharma
    • 1
  • George Joseph
    • 1
  1. 1.Division of Biosurface TechnologyBMT Wing, Sree Chitra Tirunal Institute for Medical Sciences and TechnologyTrivandrumIndia

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