Abstract
Segmented polyurethanes, introduced as new elastomeric materials for biomedical application in 19671 , have found increasing attention as blood-compatible materials for vascular repair and cardiovascular devices2–6. These thermoplastic elastomers are block copolymers generally composed of short polyurethane sequences (from aromatic diisocyanates extended with low molecular weight diols or diamines, hard segments) connected to long and flexible polyether or polyester chains (soft segments). These materials show a combination of properties not easily available in other materials: high modulus of elasticity and resistance to flex-fatigue6,7, together with a considerable degree of blood compatibility which has been the subject of various investigations2,8–11.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. W. Boretos and W. S. Pierce, Segmented polyurethane. A new elastomer for biomedical applications, Science, 158:1481 (1967).
International Colloquium “Polyurethane in Medical Technics” Fell-bach (Germany), January 27–29, 1983, Polyurethanes in Biomedical Engineering, 1, H. Planck, G. Egbers, I.Syré, eds. Amsterdam, Oxford, New York, Tokyo: Elsevier (1984).
D. L. Lyman, W. J. Seare, Jr., D. Albo, Jr., S. Bergman, J. Lamb,L.C. Metcalf and K. Richards, Polyurethane Elastomers in Surgery, Int. J. Polymeric Mater. 5:211 (1977)
G. L. Wilkes, Necessary considerations for selecting a polymeric material for implantation with emphasis on polyurethanes, in: “Polymer Science and Technology (vol. 8): Polymers in Medicine and Surgery” R. L. Kronenthal, Z. Oser and C. Martin eds., Plenum Press, New York, London (1975).
J. W. Boretos, D. E. Detmer and J. H. Donachy, Segmented polyurethanes: a polyether polymer, II. Two years experience, J. Biomed. Mater. Res., 5:373 (1971).
E. Nyilas, Development of blood compatible elastomers. II. Performance ce of Avcothane blood contact surfaces in experimental animal implantations, J. Biomed. Mater. Res., 3:97 (1972)
B. D. Ratner and R. W. Paynter, Polyurethane surfaces: the importance of molecular weight distribution, bulk chemistry and casting conditions, in ref. 2, pag. 41.
S. K. Hunter, D. E. Gregoris, D. L. Coleman, B. Hanover, R. L. Stephen and S. C. Jacobsen, Surface modification of polyurethane to promote long-term potency of peritoneal access devices, Trans. Am. Soc. Artif. Int. Organs, 29:250 (1983).
P. M. Knight and D. J. Lyman, Evaluation of thrombogenicity of selected microporous oxigenator membranes, Artificial Organs, 9:28 (1985).
D. J. Lyman, L. C. Metcalf, D. Albo, Jr., K. F. Richards and J. Lamb, The effect of chemical structure and surface properties of synthe tic polymers on the coagulation of blood. III. In vivo adsorption of proteins on polymer surface. Trans. Am. Soc. Artif. Int. Organs, 20:474 (1974).
D. J. Lyman, K. Kunston, B. McNeill and K. Shibatani, The effects of chemical structure and surface properties of synthetic polymers on the coagulation of blood. IV. The relation between polymer morphology and protein adsorption. Trans. Am. Soc. Artif. Int. Organs, 21:49 (1975).
M. C. Tanzi, Italian Patent Appl. n° 20868 A/84.
H. Rinke, Elastomeric fibers based on polyurethanes, Angew. Chem. Int. Ed., 8:419 (1962).
D. J. Lyman, Polyurethanes. I. The solution polymerization of diiso cyanates with ethylene glycol. J. Polymer Sci., 55:49 (1960).
M. C.Tanzi, C.Barozzi, G. Tieghi, L. Grassi and R. Fumero, New poly(ether-amidoamine-urea-urethane) block copolymers for biomedical use, International Workshop: “Future Trends on Polymer Science and Technology. Polymers: Commodities of Specialities?”Capri, October 8–12 (1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Tanzi, M.C., Albonico, P., Barozzi, C., Bolognesi, A., Fumero, R., Tieghi, G. (1986). Heparinizable Segmented Polyurethanes for Cardio-Vascular Applications. In: Chiellini, E., Giusti, P., Migliaresi, C., Nicolais, L. (eds) Polymers in Medicine II. Polymer Science and Technology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1809-5_7
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1809-5_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9012-4
Online ISBN: 978-1-4613-1809-5
eBook Packages: Springer Book Archive