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Heparinizable Segmented Polyurethanes for Cardio-Vascular Applications

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Polymers in Medicine II

Part of the book series: Polymer Science and Technology ((POLS,volume 34))

Abstract

Segmented polyurethanes, introduced as new elastomeric materials for biomedical application in 19671 , have found increasing attention as blood-compatible materials for vascular repair and cardiovascular devices2–6. These thermoplastic elastomers are block copolymers generally composed of short polyurethane sequences (from aromatic diisocyanates extended with low molecular weight diols or diamines, hard segments) connected to long and flexible polyether or polyester chains (soft segments). These materials show a combination of properties not easily available in other materials: high modulus of elasticity and resistance to flex-fatigue6,7, together with a considerable degree of blood compatibility which has been the subject of various investigations2,8–11.

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References

  1. J. W. Boretos and W. S. Pierce, Segmented polyurethane. A new elastomer for biomedical applications, Science, 158:1481 (1967).

    Article  ADS  Google Scholar 

  2. International Colloquium “Polyurethane in Medical Technics” Fell-bach (Germany), January 27–29, 1983, Polyurethanes in Biomedical Engineering, 1, H. Planck, G. Egbers, I.Syré, eds. Amsterdam, Oxford, New York, Tokyo: Elsevier (1984).

    Google Scholar 

  3. D. L. Lyman, W. J. Seare, Jr., D. Albo, Jr., S. Bergman, J. Lamb,L.C. Metcalf and K. Richards, Polyurethane Elastomers in Surgery, Int. J. Polymeric Mater. 5:211 (1977)

    Article  Google Scholar 

  4. G. L. Wilkes, Necessary considerations for selecting a polymeric material for implantation with emphasis on polyurethanes, in: “Polymer Science and Technology (vol. 8): Polymers in Medicine and Surgery” R. L. Kronenthal, Z. Oser and C. Martin eds., Plenum Press, New York, London (1975).

    Google Scholar 

  5. J. W. Boretos, D. E. Detmer and J. H. Donachy, Segmented polyurethanes: a polyether polymer, II. Two years experience, J. Biomed. Mater. Res., 5:373 (1971).

    Article  Google Scholar 

  6. E. Nyilas, Development of blood compatible elastomers. II. Performance ce of Avcothane blood contact surfaces in experimental animal implantations, J. Biomed. Mater. Res., 3:97 (1972)

    Article  Google Scholar 

  7. B. D. Ratner and R. W. Paynter, Polyurethane surfaces: the importance of molecular weight distribution, bulk chemistry and casting conditions, in ref. 2, pag. 41.

    Google Scholar 

  8. S. K. Hunter, D. E. Gregoris, D. L. Coleman, B. Hanover, R. L. Stephen and S. C. Jacobsen, Surface modification of polyurethane to promote long-term potency of peritoneal access devices, Trans. Am. Soc. Artif. Int. Organs, 29:250 (1983).

    Google Scholar 

  9. P. M. Knight and D. J. Lyman, Evaluation of thrombogenicity of selected microporous oxigenator membranes, Artificial Organs, 9:28 (1985).

    Article  Google Scholar 

  10. D. J. Lyman, L. C. Metcalf, D. Albo, Jr., K. F. Richards and J. Lamb, The effect of chemical structure and surface properties of synthe tic polymers on the coagulation of blood. III. In vivo adsorption of proteins on polymer surface. Trans. Am. Soc. Artif. Int. Organs, 20:474 (1974).

    Google Scholar 

  11. D. J. Lyman, K. Kunston, B. McNeill and K. Shibatani, The effects of chemical structure and surface properties of synthetic polymers on the coagulation of blood. IV. The relation between polymer morphology and protein adsorption. Trans. Am. Soc. Artif. Int. Organs, 21:49 (1975).

    Google Scholar 

  12. M. C. Tanzi, Italian Patent Appl. n° 20868 A/84.

    Google Scholar 

  13. H. Rinke, Elastomeric fibers based on polyurethanes, Angew. Chem. Int. Ed., 8:419 (1962).

    Google Scholar 

  14. D. J. Lyman, Polyurethanes. I. The solution polymerization of diiso cyanates with ethylene glycol. J. Polymer Sci., 55:49 (1960).

    ADS  Google Scholar 

  15. M. C.Tanzi, C.Barozzi, G. Tieghi, L. Grassi and R. Fumero, New poly(ether-amidoamine-urea-urethane) block copolymers for biomedical use, International Workshop: “Future Trends on Polymer Science and Technology. Polymers: Commodities of Specialities?”Capri, October 8–12 (1984).

    Google Scholar 

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© 1986 Plenum Press, New York

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Tanzi, M.C., Albonico, P., Barozzi, C., Bolognesi, A., Fumero, R., Tieghi, G. (1986). Heparinizable Segmented Polyurethanes for Cardio-Vascular Applications. In: Chiellini, E., Giusti, P., Migliaresi, C., Nicolais, L. (eds) Polymers in Medicine II. Polymer Science and Technology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1809-5_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1809-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9012-4

  • Online ISBN: 978-1-4613-1809-5

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