Improved Activation of Macrophages by Polyanionic Polymers Encapsulated in Mannan Derivative-Coated Liposomes

  • Raphael M. Ottenbrite
  • Junzo Sunamoto
Part of the Polymer Science and Technology book series (POLS, volume 34)

Abstract

Both of the authors of this article attended the first international symposium on “Polymers in Medicine”, which was held in Porto Cervo, Sardinia, Italy, in 1983. Ottenbrite presented a paper on the synthesis and biological characterization of several polyanionic polymers such as the copolymers of itaconic acid and styrene, maleic anhydride and styrene, and maleic anhydride and cyclohexyl-l,3-dioxepin. He reported that some of these copolymers had the unique feature of exhibiting immunomodulator activity(l). The other author, Sunamoto, presented a paper at the same meeting concerning a new technique for stabilizing liposomes to be used effectively as drug delivery systems(2). He had developed a unique method of coating liposomes with derivatives of naturally occuring polysaccharides. This process not only made the liposomes more stable against chemical and/or enzymatic stimuli, but also targetable to specific cells, such as alveolar macrophages and specific lung tissue.

Keywords

Toxicity Superoxide Polysaccharide Fractionation Interferon 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R.M. Ottenbrite, K. Kuus, and A.M. Kaplan, Polymers in Medicine, eds., E. Chiellini, and P. Giusti, Plenum Publishing Co., New York, p.3 (1982).Google Scholar
  2. 2.
    J. Sunamoto, K. Iwamoto, M. Takada, T. Yuzuriha, and K. Katayama, Polymers in Medicine, eds., E. Chiellini, P. Giusti, Plenum Publishing Co., p.157 (1984).Google Scholar
  3. 3.
    R.M. Ottenbrite, and G.B. Butler, Anticancer and Interferon Agents, Marcel Decker, Inc.,New York, (1984).Google Scholar
  4. 4.
    L.G. Donaruma, R.M. Ottenbrite, and O. Vogal, eds., Anionic Polymeric Drugs, John Wiley and Sons, New York, (1980).Google Scholar
  5. 5.
    W.J. Freeman, and D.S. Breslow, in Biological Activities of Polymers, eds., C.E. Carraher, and C.G. Gebelein, ACS Symp. Ser. 186, American Chemical Society, Washington, D.C., p.243 (1982).CrossRefGoogle Scholar
  6. 6.
    W. Regelson, A. Munson, and W. Wooles, Int. Symp. Stand. Interferon and Interferon Inducers, London, 1969; Symp. Series Immunobiol. Stand., 14, Karger, Basel, p.227 (1970).Google Scholar
  7. 7.
    A.M. Kaplan, R.M. Ottenbrite, W. Regelson, R. Carchman, P. Morahan, and A. Munson, in Handbook of Cancer and Immunology, 5, ed. H. Walters, Garland, New York, p.135 (1978).Google Scholar
  8. 8.
    R.M. Schultz, J.D. Papamatheakis, and M.A. Chirigos, in Immune Modulation and Control of Neoplasia by Adjuvant Therapy, ed. M.A. Chirigos, Raven Press, New York, p.459 (1978).Google Scholar
  9. 9.
    A.E. Munson, W. Regelson, W. Lawrence, and W.R. Wooles, J. Reticuloendothel. Soc., 7, p.375 (1970).Google Scholar
  10. 10.
    F.F. Pindak, Infect. Immun.; 1, 271 (1970).Google Scholar
  11. 11.
    P.S. Morahan, W. Regelson, and A.E. Munson, Antimicrob. Agents Chemother., 3, 16 (1972).Google Scholar
  12. 12.
    P.S. Roberts, W. Regelson, and B. Kingsbury, J. Lab. and Chemical Med., 2, 822 (1973).Google Scholar
  13. 13.
    M.A. Chirigos, ed., Control of Neoplasia by Modulation of the Immune System, 3, Raven Press, New York, (1977).Google Scholar
  14. 14.
    M.W. Rosenthal, M.W. Argonne National Laboratory, Argonne, Illinois, personal communication.Google Scholar
  15. 15.
    A.M. Kaplan, in Anionic Polymeric Drugs, eds., L.G. Donaruma, R.M. Ottenbrite, and O. Vogl, John Wiley and Sons, New York, p.227 (1980).Google Scholar
  16. 16.
    P.S. Morahan, D.W. Barnes, and A.E. Munson, in Anionic Polymeric Drugs, eds., L.G. Donaruma, R.M. Ottenbrite, and O. Vogl, John Wiley and Sons, New York, (1980).Google Scholar
  17. 17.
    R.M. Ottenbrite, E.M. Goodell, and A.E. Munson, Polymer, 18, 461 (1977).CrossRefGoogle Scholar
  18. 18.
    K. Takemoto, R.M. Ottenbrite, and I.Inaki, eds., Functionalized Polymers, Marcel Dekker, New York, (in press).Google Scholar
  19. 20.
    R.M. Ottenbrite, and A.M. Kaplan, Polymer Preprints, 23, 205 (1982).Google Scholar
  20. 21.
    K. Kuus, PhD., Dissertation, “Macrophage Activation by Unique Poly-anionic Polymers”, Virginia Commonwealth University, 1983.Google Scholar
  21. 22.
    K. Kuus, R.M. Ottenbrite, A.M. Kaplan, J. Bio. Resp. Mod., 4, 46 (1985).Google Scholar
  22. 23.
    S.A. Cohen, D. Salazar, and J.P. Nolan, J. Immunol., 129, 495 (1982).Google Scholar
  23. 24.
    K.C. Lee, M. Wong, and D. McIntyre, J. Immunol., 126, 2474 (1981).Google Scholar
  24. 25.
    J. Sunamoto, K. Iwamoto, M. Takada, T. Yuzuriha, and K. Katayama, Polymers in Medicine, eds., E. Chiellini and P. Giusti, Plenum Publishing Co., p.157 (1984).Google Scholar
  25. 26.
    J. Sunamoto, K. Iwamoto, M. Takada, T. Yuzuriha, and K.Katayama, Recent Advances in Drug Delivery Systems, eds., J.M. Anderson, and S.W. Kim, Plenum Publishing Co., New York, p.153 (1984).CrossRefGoogle Scholar
  26. 27.
    J. Sunamoto, M. Goto, T. Iida, K. Hara, A. Saito, and A. Tomonaga, Receptor-Mediated Targeting of Drugs, eds., G. Gregoradis, G. Poste, J. Senior, and A. Trouet, Plenum Publishing Co., New York, p.359 (1985).Google Scholar
  27. 28.
    M. Takada, T. Yuzuriha, K. Katayama, K. Iwamoto, and J. Sunamoto, Biochem. Biophys. Acta., 802, 237 (1984).Google Scholar
  28. 29.
    I.J. Fidler, S. Sone, W.E. Fogler, and Z.L. Barnes, Proc. Nat. Acad. Sci., USA, 78, 1680 (1981).ADSCrossRefGoogle Scholar
  29. 30.
    J. Sunamoto, T. Sato, and R.M. Ottenbrite, in Current Topics in Polymer Science, eds., R.M. Ottenbrite, S. Inoue, and L.A. Utracki, McMillan Pub. Co., (in press).Google Scholar
  30. 31.
    R.M. Ottenbrite, J. Sunamoto, T. Sato, and M. Oka, Polymer Preprints, 26, 212 (1985).Google Scholar
  31. 32.
    P.G. Holt, J. Immuno. Methods, 27, 189 (1979).Google Scholar
  32. 33.
    J.J. Reinehart, P. Lange, B.J. Gormus, and M.E. Kaplan, Blood, 52, 211 (1978).Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Raphael M. Ottenbrite
    • 1
  • Junzo Sunamoto
    • 2
  1. 1.Department of Chemistry and Massey Cancer CenterVirginia Commonwealth UniversityRichmondUSA
  2. 2.Department of Industrial Chemistry, Faculty of EngineeringNagasaki UniversityNagasaki 852Japan

Personalised recommendations