Organic Dementia of the Alzheimer Type

Possible Role of Reactivated Herpes Simplex Virus
  • Melvyn J. Ball

Abstract

To our knowledge, the possible effect of aging on the nerve cell population in the Gasserian ganglion of man had not yet been reported as of 1981. During a morphometric investigation of this question in collaboration with Dr. Kenneth Warren (Ball et al., 1982), it readily became apparent that large numbers of lymphoctyes were also present in the stroma of the human trigeminal (or semilunar) ganglion.

Keywords

Dementia Neurol Hematoxylin Eosin Encephalitis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abercrombie, M., 1946, Estimation of nuclear population from microtome sections, Anat. Rec. 94:239–247.PubMedCrossRefGoogle Scholar
  2. Aldskogius, H., and Arvidsson, J., 1978, Nerve cell degeneration and death in the trigeminal ganglion of the adult rat following peripheral nerve transection, J. Neurocytol. 7:229–250.PubMedCrossRefGoogle Scholar
  3. Ball, M. J., 1982, Limbic predilection in Alzheimer dementia: Is reactivated herpes involved? Can. J. Neurol. Sci. 9:303–306.PubMedGoogle Scholar
  4. Ball, M. J., Nuttall, K., and Warren, K. G., 1982, Neuronal and lymphocytic populations in human trigeminal ganglia: Implications for ageing and for latent virus, Neuropathol. Appl. Neurobiol. 8:177–187.PubMedCrossRefGoogle Scholar
  5. Gregg, J. M., and Dixon, A. D., 1973, Somatotopic organization of the trigeminal ganglion of the rat, Arch. Oral. Biol. 18:487–498.PubMedCrossRefGoogle Scholar
  6. Ishizaki, T., 1972, Lymphocytic and plasma cell infiltration in the human trigeminal ganglia, Clin. Neurol. 112:596–600.Google Scholar
  7. Opalski, A., 1930, Zür normalen und pathologischen Anatomie des Ganglion Gasseri, Z. Ges. Neurol. Psychiatr. 124:383–419.CrossRefGoogle Scholar
  8. Taylor, G. R., Crow, T. J., Markakis, D. A., Lofthouse, R., Neeley, S., and Carter, G. I., 1984, Herpes simplex virus and Alzheimer’s disease: A search for virus DNA by spot hybridisation, J. Neurol. Neurosurg. Psychiatry 47:1061–1065.PubMedCrossRefGoogle Scholar
  9. Windle, W. F., 1926, The distribution and probable significance of unmyelinated nerve fibres in the trigeminal nerve of the cat, J. Comp. Neurol. 41:453–477.CrossRefGoogle Scholar
  10. Young, R. F., 1977, Fiber spectrum of the trigeminal sensory root of the frog, cat and man determined by electron microscopy, in: Pain in the Trigeminal Region (D. J. Anderson and B. Matthews, eds.), Elsevier-North Holland, Amsterdam, pp. 137–147.Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Melvyn J. Ball
    • 1
  1. 1.Departments of Pathology, Clinical Neurological Sciences, and PsychiatryUniversity of Western OntarioLondonCanada

Personalised recommendations