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Immunologic Abnormalities in Depressive Illness

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Abstract

There is now a large body of evidence suggesting strong and complex interactions between the central nervous system and the immune system (Ader, 1981). Lesions in certain areas of the brain are accompanied by specific immune changes (Stein et al., 1976). Several immunologic phenomena are accompanied by increased neuronal firing in specific areas of the brain as well as a disturbance in neuroendocrine regulation (Besedovsky and Sorkin, 1977). Stressed animals exhibit an increased susceptibility to a variety of immune-related disorders such as allergy and cancer (Riley, 1981) as well as impairment in specific immunologic functions such as lymphoblast transformation and granulocyte phagocytosis (Monjan and Collector, 1977).

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© 1987 Springer Science+Business Media New York

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Kronfol, Z., Quinn, J., House, J.D., Nasrallah, H.A. (1987). Immunologic Abnormalities in Depressive Illness. In: Kurstak, E., Lipowski, Z.J., Morozov, P.V. (eds) Viruses, Immunity, and Mental Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1799-9_33

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  • DOI: https://doi.org/10.1007/978-1-4613-1799-9_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9007-0

  • Online ISBN: 978-1-4613-1799-9

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