T Lymphocytes in Schizophrenics and Normals and the Effects of Varying Antipsychotic Dosage

  • Rohan Ganguli
  • Bruce Rabin
  • Usha Raghu
  • Richard S. Ulrich


A number of investigations over the last 30–40 years have reported finding immunologic abnormalities in schizophrenic patients. Early investigators focused on humoral antibodies, and some studies found abnormal levels of immunoglobulin, but others did not (see Solomon, 1981, for a review). More recent studies have focused on cells, i.e., lymphocytes, that mediate the immune response either directly or through the production of antibodies. Hirata-Hibi et al. (1982) had for some years been reporting that they found abnormally large numbers of morphologically “atypical lymphocytes” in schizophrenic patients and further asserted that these cells were probably activated T cells. Advances in technology now allow characterization of lymphocyte subsets quite accurately without resorting to morphological description.


Antipsychotic Drug Schizophrenic Patient Lymphocyte Subset Lymphocyte Subpopulation Chronic Patient 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Rohan Ganguli
    • 1
  • Bruce Rabin
    • 2
  • Usha Raghu
    • 1
  • Richard S. Ulrich
    • 3
  1. 1.University of Pittsburgh School of Medicine, and Western Psychiatric Institute and ClinicPittsburghUSA
  2. 2.Clinical Immunopathology LaboratoryUniversity of Pittsburgh School of MedicinePittsburghUSA
  3. 3.Western Psychiatric Institute and ClinicPittsburghUSA

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