Advertisement

T Lymphocytes in Schizophrenics and Normals and the Effects of Varying Antipsychotic Dosage

  • Rohan Ganguli
  • Bruce Rabin
  • Usha Raghu
  • Richard S. Ulrich

Abstract

A number of investigations over the last 30–40 years have reported finding immunologic abnormalities in schizophrenic patients. Early investigators focused on humoral antibodies, and some studies found abnormal levels of immunoglobulin, but others did not (see Solomon, 1981, for a review). More recent studies have focused on cells, i.e., lymphocytes, that mediate the immune response either directly or through the production of antibodies. Hirata-Hibi et al. (1982) had for some years been reporting that they found abnormally large numbers of morphologically “atypical lymphocytes” in schizophrenic patients and further asserted that these cells were probably activated T cells. Advances in technology now allow characterization of lymphocyte subsets quite accurately without resorting to morphological description.

Keywords

Antipsychotic Drug Schizophrenic Patient Lymphocyte Subset Lymphocyte Subpopulation Chronic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Coffey, C. E., Sullivan, J. L., and Rice, J. R., 1983, T-lymphocytes in schizophrenia, Biol. Psychiatry 18:113–119.PubMedGoogle Scholar
  2. DeLisi, L. E., Goodman, S., Neckers, L. M., and Wyatt, R. J., 1982, An analysis of lymphocyte subpopulations in schizophrenic patients, Biol. Psychiatry 17:1003–1009.PubMedGoogle Scholar
  3. Duorakova, M., Zuolsky, P., and Herzog, P., 1980, Endogenous psychoses and T and B lymphocytes, Folia Haematol. 107:221–228.Google Scholar
  4. Ferguson, R. M., Schmidtke, J. R., and Simmons, R. L., 1978, Effects of antipsychotic drugs on in-vitro lymphocyte activation, Birth Defects 14:379–405.PubMedGoogle Scholar
  5. Hirata-Hibi, M., Higashi, S., Tachibana, T., and Watanabe, N., 1982, Stimulated lymphocytes in schizophrenia, Arch. Gen. Psychiatry 39:82–87.PubMedCrossRefGoogle Scholar
  6. Loseva, T. M., 1977, Thymus-dependent lymphocytes in the spontaneous rosette-formation reaction in schizophrenia, Zh. Nevropat. Psikhiat. 77:992–995.Google Scholar
  7. Nyland, H., Naess, A., and Lundle, H., 1980, Lymphocyte subpopulations in the peripheral blood from schizophrenic patients, Acta Psychiatr. Scand. 61:313–318.PubMedCrossRefGoogle Scholar
  8. Schleifer, S. J., Keller, S. E., Camerino, M., Thornton, J. C., and Stein, M., 1983, Suppression of lymphocyte stimulation following bereavement, J.A.M.A. 250:374–377.PubMedCrossRefGoogle Scholar
  9. Solomon, G. F., 1981, Immunologic abnormalities in mental illness, in: Psychoimmunology (R. Ader, ed.), Academic Press, New York, pp. 259–278.Google Scholar
  10. Vartanian, M. E., Kolyaskina, G. E., Lozovsky, D. V., Burbava, G. S., and Ignatov, S. A., 1978, Aspects of humoral and cellular immunity in schizophrenics, Birth Defects 14:339–364.PubMedGoogle Scholar
  11. Zarrabi, M. H., Zucker, S., Miller, F., Derman, R. M., Romeno, G. S., Hartnett, J. A., and Varma, A. O., 1979, Immunologic and coagulation disorders in chlorpromazine treated patients, Ann. Intern. Med. 91:194–199.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Rohan Ganguli
    • 1
  • Bruce Rabin
    • 2
  • Usha Raghu
    • 1
  • Richard S. Ulrich
    • 3
  1. 1.University of Pittsburgh School of Medicine, and Western Psychiatric Institute and ClinicPittsburghUSA
  2. 2.Clinical Immunopathology LaboratoryUniversity of Pittsburgh School of MedicinePittsburghUSA
  3. 3.Western Psychiatric Institute and ClinicPittsburghUSA

Personalised recommendations