T Lymphocytes in Schizophrenics and Normals and the Effects of Varying Antipsychotic Dosage
A number of investigations over the last 30–40 years have reported finding immunologic abnormalities in schizophrenic patients. Early investigators focused on humoral antibodies, and some studies found abnormal levels of immunoglobulin, but others did not (see Solomon, 1981, for a review). More recent studies have focused on cells, i.e., lymphocytes, that mediate the immune response either directly or through the production of antibodies. Hirata-Hibi et al. (1982) had for some years been reporting that they found abnormally large numbers of morphologically “atypical lymphocytes” in schizophrenic patients and further asserted that these cells were probably activated T cells. Advances in technology now allow characterization of lymphocyte subsets quite accurately without resorting to morphological description.
KeywordsSchizophrenia Stein Prolactin Chlorpromazine Zucker
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