In Vitro Cultivation of Nerve Cells as a Model for Studies on Nerve Cell—Virus Interactions

  • Richard J. Ziegler


During the last decade, nerve tissue culture techniques have been applied to fundamental questions concerning the mechanisms of nervous system development and function. Culture conditions have varied from complex growth media to chemically defined growth media. Research has focused on such diverse topics as (1) electrophysiological properties, (2) neurotransmitter uptake and release, (3) neuropeptide content, (4) influence of trophic factors, (5) neurochemical receptor binding, (6) receptor-mediated cellular activation, i.e., stimulation of cAMP or cGMP synthesis, (7) synapse formation, and (8) axonal transport. This extensive literature forms a basis for future studies of viral effects on neural function.


Schwann Cell Neural Tissue Rabies Virus Continuous Cell Line Human Neuroblastoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Richard J. Ziegler
    • 1
  1. 1.Department of Virology, Institute of Medical MicrobiologyUniversity of GöteborgGöteborgSweden

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