Proteins pp 445-453 | Cite as

The Protein Identification Resource (PIR): An On-Line Computer System for the Characterization of Proteins Based on Comparisons with Previously Characterized Protein Sequences

  • David G. George
  • Winona C. Barker
  • Lois T. Hunt

Abstract

This conference is dedicated to examining new methods for the isolation and characterization of proteins. One extremely effective method for the characterization of a new protein involves the comparison of its amino acid sequence with the sequences of previously determined proteins. Although: this method is not new (but dates back to the early days of protein sequencing methodology), the wealth of information available is only recently being fully appreciated. The rapid increase in the accumulation of sequence data, owing to recombinant DNA technology, has greatly heightened interest in this area and has made large database searching a much more fruitful enterprise. The primary structures of well over 3, 000 proteins containing almost three quarters of a million residues are now known, more than double what was known just 5 years ago.

Keywords

Tyrosine Polypeptide Trypsin Macromolecule Catalase 

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • David G. George
    • 1
  • Winona C. Barker
    • 1
  • Lois T. Hunt
    • 1
  1. 1.National Biomedical Research FoundationGeorgetown University Medical CenterWashingtonUSA

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