Abstract
The advent of recombinant DNA methodology has introduced a situation in which protein structures are being determined indirectly (via deduction from DNA) at a much faster rate than directly by Edman degradation and other protein methods. Deduction of a protein sequence from the DNA is an important first step in structure determination. However, proteins may undergo a wide range of post-translational modifications (1), most of which cannot yet be accurately predicted from the primary structure. These processing events are often crucial for expression of biological activity. Detailed structure determination still requires laborious and time consuming methods.
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© 1987 Plenum Press, New York
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Andrews, P.C., Dixon, J.E. (1987). Pancreatic Preprosomatostatin Processing: Isolation and Structure of Intermediates and Final Products of Processing. In: L’Italien, J.J. (eds) Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1787-6_30
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DOI: https://doi.org/10.1007/978-1-4613-1787-6_30
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9001-8
Online ISBN: 978-1-4613-1787-6
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