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The Right Ventricle pp 141–184Cite as

Pulmonary Vascular Disease

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 83))

Abstract

It may be asked whether the marriage between the heart and the lungs is one of passion or one of convenience. It appears to be one of convenience, as it does not work well when one partner makes excessive demands of the other. Disorders of the heart will result in pulmonary congestion and pulmonary vascular disease, and disorders of the lung will cause right heart failure. This chapter will discuss the many clinical conditions likely to cause pulmonary vascular disease and, in each case, what is known about the pathophysiology and how this is influencing our current approach to treatment. Often, our therapy has been less than satisfactory because we lack a comprehensive understanding of how the structural changes develop and why they result in abnormal hemodynamic behavior of the pulmonary circulation. Current research is therefore being directed toward identifying specific alterations in the cell biology of the vessel wall and in assessing their functional significance. The ultimate goal will be to elucidate the important underlying molecular genetic control mechanisms and manipulate them to advantage.

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  1. Marlene Rabinovitch
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Editors and Affiliations

  1. Tufts University School of Medicine, 750 Washington Street, 02111, Boston, MA, USA

    Marvin A. Konstam M.D. (Associate Professor of Medicine and Radiology, Director) & Jeffrey M. Isner M.D. (Associate Professor of Medicine and Pathology, Associate Director) (Associate Professor of Medicine and Radiology, Director) &  (Associate Professor of Medicine and Pathology, Associate Director)

  2. Adult Cardiac Catheterization and Cardiac Nuclear Medicine Laboratories, New England Medical Center, 750 Washington Street, 02111, Boston, MA, USA

    Marvin A. Konstam M.D. (Associate Professor of Medicine and Radiology, Director) (Associate Professor of Medicine and Radiology, Director)

  3. Adult Cardiac Catheterization Laboratory, New England Medical Center Hospitals, 750 Washington Street, 02111, Boston, MA, USA

    Jeffrey M. Isner M.D. (Associate Professor of Medicine and Pathology, Associate Director) (Associate Professor of Medicine and Pathology, Associate Director)

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© 1988 Kluwer Academic Publishers

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Rabinovitch, M. (1988). Pulmonary Vascular Disease. In: Konstam, M.A., Isner, J.M. (eds) The Right Ventricle. Developments in Cardiovascular Medicine, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1773-9_8

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  • DOI: https://doi.org/10.1007/978-1-4613-1773-9_8

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