Hematopoietic Hormones in Transfusion Medicine

  • W. G. Ho
Part of the Developments in Hematology and Immunology book series (DIHI, volume 21)


The regulation of blood cell production is a complex process of proliferation and differentiation of progenitor cells of the bone marrow in response to glycoprotein hormones termed colony stimulating factors (CSFs). The development of in vitro culture systems of bone marrow cells in semisolid media [1,2] led to the establishment of appropriate cell culture systems for the study of the clonal growth of hematopoietic cells. CSF research in this field has recently been intensified for reasons beyond mere scientific interest. Dysfunction of the hematopoietic system results in diseases that are major medical problems. The possibility that CSFs could function as regulators of blood cell production suggest distinct therapeutic approaches to these disorders thereby adding impetus to research.


Sickle Cell Anemia Mouse Bone Marrow Cell Human Granulocyte Colony Stimulate Factor Blood Cell Production Major Medical Problem 
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© Kluwer Academic Publishers, Boston 1988

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  • W. G. Ho

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