Advertisement

Hematopoietic Hormones in Transfusion Medicine

  • W. G. Ho
Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 21)

Abstract

The regulation of blood cell production is a complex process of proliferation and differentiation of progenitor cells of the bone marrow in response to glycoprotein hormones termed colony stimulating factors (CSFs). The development of in vitro culture systems of bone marrow cells in semisolid media [1,2] led to the establishment of appropriate cell culture systems for the study of the clonal growth of hematopoietic cells. CSF research in this field has recently been intensified for reasons beyond mere scientific interest. Dysfunction of the hematopoietic system results in diseases that are major medical problems. The possibility that CSFs could function as regulators of blood cell production suggest distinct therapeutic approaches to these disorders thereby adding impetus to research.

Keywords

Sickle Cell Anemia Mouse Bone Marrow Cell Human Granulocyte Colony Stimulate Factor Blood Cell Production Major Medical Problem 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Pluznik DH, Sachs J. The cloning of normal mast cells in tissue culture. J Cell Comp Physiol 1965;66:319–24.CrossRefGoogle Scholar
  2. 2.
    Bradley TR, Metcalf D. The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci 1966;44:287–300.PubMedCrossRefGoogle Scholar
  3. 3.
    Metcalf D, Nicola NA. Proliferative effects of purified granulocyte stimulating factor (G-CSF) on normal mouse hematopoietic cells. J Cell Physiol 1983;116: 198–206.PubMedCrossRefGoogle Scholar
  4. 4.
    Stanley ER, Heard PM. Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L-cells. J Biol Chem 1977;252:4305–12.PubMedGoogle Scholar
  5. 5.
    Ihle JN, Keller J, Orozlan S et al. Biologic properties of homogeneous inter-leukin-3. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, P cell stimulating factor activity, colony stimulating factor activity and histamine producing cell-stimulating factor activity. J Immunol 1983;131: 282–87.PubMedGoogle Scholar
  6. 6.
    Metcalf D. Review: The molecular biology and functions of the granulocyte-macrophage colony stimulating factors. Blood 1986;67:257–67.PubMedGoogle Scholar
  7. 7.
    Erslev A. Humoral regulation of red cell production. Blood 1953;8:349–57.PubMedGoogle Scholar
  8. 8.
    Smith KA, Lachman LB, Oppenheim JJ, Favata MF. The functional relationship of the interleukins. J Exp Med 1980;151:1551–6.PubMedCrossRefGoogle Scholar
  9. 9.
    Stanley ER, Bartocci A, Patinkin D, Rosendaal M, Bradley TR. Regulation of very primitive, multipotent hemopoietic cells by hemopoietin-1. Cell 1986;45: 667–74.PubMedCrossRefGoogle Scholar
  10. 10.
    Dinarello CA. An update on human interleukin-1: from molecular biology to clinical relevance. J Clin Immunol 1985;5:287–97.PubMedCrossRefGoogle Scholar
  11. 11.
    Yokota T, Otsaka T, Mosmann T et al. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor I, that expresses B-cell and T-cell stimulating activities. Proc Natl Acad Sci (USA) 1986;83:5894–8.CrossRefGoogle Scholar
  12. 12.
    Jourdanet D. De l’anémie des altitudes et de l’anemie en general dans ses rapports avec la pression de l’atmosphère. Bailliere, Paris 1863.Google Scholar
  13. 13.
    Reissman KR. Studies of the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood 1950;5:372–80.Google Scholar
  14. 14.
    Miyake T, Kung CK, Goldwasser E. Purification of human erythropoietin. J Biol Chem 1977;252:5558–64.PubMedGoogle Scholar
  15. 15.
    Jacobs K, Shoemaker C, Rudersdorf et al. Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature 1985;313:806–10.PubMedCrossRefGoogle Scholar
  16. 16.
    Winearls CG, Oliver DO, Pippard MJ, Reid C, Downing MR, Cotes PM. Effect on the anemia of patients maintained by chronic hemodialysis. Lancet 1986;ii:1175–8.CrossRefGoogle Scholar
  17. 17.
    Eschbach JW, Egrie JC, Downing MR, Browne JK, Admanson JW. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin: Results of a phase I and II clinical trial. N Engl J Med 1987;316:73–8.PubMedCrossRefGoogle Scholar
  18. 18.
    Surgenor DM. The patient’s blood is the safest blood. N Engl J Med 1987;316: 542–4.PubMedCrossRefGoogle Scholar
  19. 19.
    Erslev JA, Anema of chronic disorders. In: Williams WJ, Beutler E, Erslev AJ, Lichtman MA (eds). Hematology. 3rd ed. McGraw-Hill, New York 1985:522–8.Google Scholar
  20. 20.
    Erslev AJ, Wilson J, Caro J. Erythropoietin titers in anemic, non uremic patients. J Lab Clin Med 1987;109:429–33.PubMedGoogle Scholar
  21. 21.
    Al-Khatti A, Veith RW, Papyannopoulou T, Frisch EF, Goldwasser E. Stimulation of fetal hemoglobin synthesis by erythropoietin in baboons. N Engl J Med 1987;317:415–20.PubMedCrossRefGoogle Scholar
  22. 22.
    Till JE, McCulloch EA. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 1961;14:213–22.PubMedCrossRefGoogle Scholar
  23. 23.
    Groopman JE, Mitsuyasu RT, DeLeo MJ, Oette DH, Golde DW. Effect of recombinant human granulocyte-macrophage colony stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. N Engl J Med 1987;317: 593–8.PubMedCrossRefGoogle Scholar
  24. 24.
    Nagata S, Tsuchiya M, Asano S et al. Molecular cloning and expression of cDNA for human granulocyte colony stimulating factor. Nature 1986;319:415–7.PubMedCrossRefGoogle Scholar
  25. 25.
    Weite K, Bonilla MA, Gillio AP et al. Recombinant human granulocyte colony-stimulating factor effects on hematopoiesis in normal and cyclophosphamide-treated primates. J Exp Med 1987;165:941–8.CrossRefGoogle Scholar
  26. 26.
    Gabrilove JL, Jakubowski A, Grous J et al. Initial results of a study of recombinant human granulocyte colony stimulating factor (rhG-CSF) in cancer patients. Exp Hematol 1987;15:461.Google Scholar
  27. 27.
    Warren MK, Ralph P. Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor and colony stimulating activity. J Immunol 1986;7:2281–5.Google Scholar
  28. 28.
    Platzer E, Weite K, Gabrilove JL et al. Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells. J Exp Med 1985;162:1788–1801.PubMedCrossRefGoogle Scholar
  29. 29.
    Lopez AF, Williamson DJ, Gamble JR et al. Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression and survival. J Clin Invest 1986;78:1220–8.PubMedCrossRefGoogle Scholar
  30. 30.
    Rosenberg SA, Lotze MT, Muul LM et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J med 1985;313:1485–92.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  • W. G. Ho

There are no affiliations available

Personalised recommendations