Advertisement

The Role of Diet in the Etiology and Causation of Breast Cancer

  • E. L. Wynder
  • L. Cohen
  • D. Rose
Part of the Developments in Oncology book series (DION, volume 56)

Abstract

Common diseases have common causes. Since 1 out of 10 women will develop breast cancer in their lifetime, the disease must have a common cause. In investigating the etiology of breast cancer, we need to determine the relative contribution made by such generally established risk factors as age of first pregnancy, late menopause, nulliparity, family history, and less well established risk factors as obesity, long-term lactation and fibrocystic disease. We believe that these risk factors cannot explain the reported differences in incidence between the United States and Japan, countries with major differences in the rates of pre- and particularly postmenopausal breast cancer. If these factors account for only a portion of the observed differences, then we need to examine other variables, that are both common and could account, at least in part, for these differences. One such factor is likely to be the consumption of dietary fat.

Keywords

Breast Cancer Breast Cancer Patient Breast Cancer Risk Established Risk Factor Postmenopausal Breast Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Wynder, E.L., Rose, D.P., and Cohen, L.A. Cancer 58:1804–1813, 1986.PubMedCrossRefGoogle Scholar
  2. 2.
    Tannenbaum, A. Cancer Res. 2:468–475, 1942.Google Scholar
  3. 3.
    Carroll, K.K. and Khor, H.T. Lipids 6:415–420, 1971.PubMedCrossRefGoogle Scholar
  4. 4.
    Carroll, K.K., Braden, L.M., Bell, J.A., and Kalamegham, R. Cancer 58:1818–1825, 1986.PubMedCrossRefGoogle Scholar
  5. 5.
    Cohen, L.A., Thompson, D.O., Maeura, Y., Choi, K., Blank, M.E., and Rose, D.P. J. Natl. Cancer Inst. 77:33–42, 1986.Google Scholar
  6. 6.
    King, M.M., Bailey, D.M., and Gibson, D.D., et al. J. Natl. Cancer Inst. 63:657–663, 1979.PubMedGoogle Scholar
  7. 7.
    Rogers, A.E. and Wetsel, W.C. Cancer Res. 41:3735, 1981.PubMedGoogle Scholar
  8. 8.
    Hopkins, G.J., Hard, C.G. and West, C.E. J. Natl. Cancer Inst. 60:849–853, 1978.Google Scholar
  9. 9.
    Cohen, L.A., Choi, K., Weisburger, J.H., and Rose, D.P. Anticancer Res. 6:215–218, 1986.PubMedGoogle Scholar
  10. 10.
    Karmali, R.A., Marsh, J., and Fuchs, C. J. Natl. Cancer Inst. 73:457–461, 1984.Google Scholar
  11. 11.
    Carroll, K.K. and Braden, L.M. Nutr. Cancer 6:254–259, 1985.CrossRefGoogle Scholar
  12. 11a.
    Cohen, L.A., Thompson, D.O., Maeura, Y., and Weisburger, J.H. Cancer Res. 44:5023–5028, 1984.PubMedGoogle Scholar
  13. 12.
    Waxier, S.H., Brecher, G., and Beal, S.L. Proc. Soc. Exp. Biol. Med. 162:365–369, 1979.Google Scholar
  14. 13.
    Sohrabi, A., Sandoz, L., Spratt, J.S., and Polk, H.C.J. J. Am. Med. Assn. 244:264–265, 1980.CrossRefGoogle Scholar
  15. 14.
    Zumoff, B., Gorzynski, J.G., Katz, J.L., Weiner, H., Levin, J., Holland, J., and Fukushima, D.K. Anticancer Res. 2:59–62, 1982.PubMedGoogle Scholar
  16. 15.
    Donegan, W.L., Hartz, A.J., and Rimm, A.A. Cancer 41:1590–1594, 1978.PubMedCrossRefGoogle Scholar
  17. 16.
    Tarttar, P.I., Papatestas, A.E., Ioannovich, J., Mulvihill, M.N., Lesnick, G. and Aupes, A.H., Jr. Cancer 47:2222–2227, 1981.CrossRefGoogle Scholar
  18. 17.
    Tannenbaum, A. Cancer Res. 2:460–467, 1942.Google Scholar
  19. 18.
    Ross, M.H. and Bras, G. J. Natl. Cancer Inst. 47:1095–1099, 1971.Google Scholar
  20. 19.
    Cohen, L.A. 78th Annual meeting, AARC. Atlanta, Ga., May 21–25, 1987.Google Scholar
  21. 20.
    Hartz, A.J., Rupley, D.C., and Rimm, A.A. Am. J. Epidemiol. 119:71–80, 1984.PubMedGoogle Scholar
  22. 21.
    Kissebah, A.H., Vydelingum, N., Murray, R., Evans, D.J., Hartz, A.J., Kalkhoff, R.K., and Adams, P.W. J. Clin. Endocrinol. Metab. 54:254–260, 1982.PubMedCrossRefGoogle Scholar
  23. 22.
    Cohen, L.A. Dietary fat and mammary cancer. In: Diet, Nutrition and cancer: A critical evaluation, vol. I. Macronutrients and cancer. (Eds. B.S. Reddy and L.A. Cohen), CRC Press, Boca Raton, FL, 1986, pp. 77–100.Google Scholar
  24. 23.
    Ip, C, Carter, CA., and Ip, M.M. Cancer Res. 45:1997–24, 1985.PubMedGoogle Scholar
  25. 24.
    Petrakis, N.L. Breast Cancer Res. Treat. 8.57–20, 1986.CrossRefGoogle Scholar
  26. 25.
    Sporer, A., Brill, D.R., and Schaffner, C.P. Urology 20:244–250, 1982.PubMedCrossRefGoogle Scholar
  27. 26.
    Sevanian, A. and Peterson, A.R. Proc. Natl. Acad. Sci. USA 81:4198–4202, 1984.PubMedCrossRefGoogle Scholar
  28. 27.
    Tanaka, T., Barnes, W.S., Weisburger, J.W. and Williams, G.M. Jap. J.Cancer Res. (Gann) 76:570–576, 1985.Google Scholar
  29. 28.
    Willett, W.C., Stampfer, M.J., Colditz, G.A., Rosner, B.A., Hennekens, C.H., and Speizer, F.E. New Engl. J. Med. 316:22–28, 1987.PubMedCrossRefGoogle Scholar
  30. 29.
    Wynder, E.L., Kajitani, T., Kuno, J., Lucas, J., De Palo, A., and Farrow, J. Surg. Gynecol. Obstet. 117:196–200, 1963.PubMedGoogle Scholar
  31. 30.
    Morrison, A.S., Lowe, C.R., MacMahon, B., et. al. Int. J. Cancer 9:470–476, 1973.CrossRefGoogle Scholar
  32. 31.
    Sakamoto, G., Sugano, H., and Hartman, W.H. Jpn. J. Cancer Clin. 25:161–170, 1979.Google Scholar
  33. 32.
    Wynder, E.L. and Cohen, L.A. Nutr. Cancer 3:195–199, 1982.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  • E. L. Wynder
    • 1
  • L. Cohen
    • 1
  • D. Rose
    • 1
  1. 1.American Health FoundationNew YorkUSA

Personalised recommendations