Cardiac Defense Mechanisms against Oxidative Damage: The Role of Superoxide Dismutase and Glutathione-Related Enzymes

  • Toshihisa Ishikawa
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)

Abstract

Cardiomyopathy resulting from oxidative damage inflicted by hyperoxia or administration of antineoplastic agents, such as adriamycin, has been well documented (1,2). The heart is the organ continuously exposed to highly oxygenated blood from the lung. Within aeroboically living cells including the cardiac cell, molecular oxygen is reduced by a number of pathways to produce reactive oxygen species, such as superoxide anion radical (O2 -), hydrogen peroxide (H2O2), hydroxyl radical (OH.) and oxygen-centered radicals of organic compounds (ROO. and RO.) (3). There is increasing evidence that these reactive oxygen species are involved in processes of cellular oxidative damage (4–7). Biological importance of reactive intermediates generating from radical-initiated peroxidative breakdown of polyunsaturated fatty acids, e.g. hydroxyalkenals, has also been implied in propagation of oxidative damage as well as in mutagenic effects and inflammatory responces (8).

Keywords

Superoxide Respiration Disulfide Thiol Cardiomyopathy 

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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Toshihisa Ishikawa
    • 1
  1. 1.Institut fur Physiologische Chemie IUniversitat DusseldorfDusseldorfGermany

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