The Role of Lipid Peroxidation in the Myocardium in Stress and Antioxidant Protection of the Heart

  • F. Z. Meerson
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)

Abstract

The past decade has shown that emotional painful stress induced by environmental factors (1,2), in the form of “anxiety neurosis” (3) or caused by an endogenous factor like myocardial infarction (4,5) involves the activation of lipid peroxidation (LP) in the myocardium. Preliminary administration of antioxidants limits or eliminates the LP activation (6,7,8) and at the same time decreases or completely eliminates diturbances of the heart metabolism, structure, contractile function (9) and electric stability (10) in emotional painful stress. These data create definite prerequisites for therapeutic and prophylactic application of antioxidants both in the primary stress damage and in the ischemic heart disease. Thus the role of LP in the pathogenesis of stress-induced damage of the heart and possibilities of its antioxidant protection constitute one of essential problems of current cardiology. This problem has been discussed in recent works (9,11), however, a number of questions remains still open.

Keywords

Glutathione Lipase Trypsin NADPH Fibril 

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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • F. Z. Meerson
    • 1
  1. 1.Laboratory of Heart PathophysiologyInstitute of General Pathology and Pathological PhysiologyMoscowUSSR

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