Abstract
Although the clinical application of interferons has resulted in some notable therapeutic successes, most common forms of cancer are proving to be resistant to interferon therapy. Failure of single-agent therapy with interferons in many neoplastic diseases has led to attempts to combine interferon with chemotherapeutic agents or with other cytokines. A cytokine widely considered as a potential anti-tumor agent is tumor necrosis factor (TNF). Although clinical trials with TNF have started only recently (1), various combinations of TNF and interferons have already been evaluated quite extensively in preclinical studies, both in tissue culture and in animals. Results of these studies will be reviewed in this article.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Blick, M., Sherwin, S.A., Rosenblum, M. and Gutterman, J. Cancer Res. 47:2986, 1987.
Carswell, E.A., Old, L.J., Kassel, R.L., Green, S., Flore, N. and Williamson, B. Proc. Natl. Acad. Sci. USA 72:3666, 1975.
Old, L.J. Science 230:630, 1985.
Aggarwal, B.B., Kohr, W.J., Hass, P.E., Moffat, B., Spencer, S.A., Henzel, W.J., Bringman, T.S., Nedwin, G.E., Goeddel, D.V. and Harkins, R.N. J. Biol. Chem. 260:2345, 1985.
Pennica, D., Nedwin, G.E., Hayflick, J.S., Seeburg, P.H., Derynck, R., Palladino, M.A., Kohr, W.J., Aggarwal, B.B. and Goeddel, D.V. Nature 312:724, 1984.
Wang, A.M., Creasey, A.A., Ladner, M.B., Lin, L.S., Strickler, J., Van Arsdell, J.N., Yamatnoto, R. and Mark, D.F. Science 228:149, 1985.
Shirai, T., Yamaguchi, H., Ito, H., Todd, C.W. and Wallace, R.B. Nature 313:803, 1985.
Williams, T.W. and Granger, G.A. Nature 219:1076, 1968.
Ruddle, N.H. and Waksman, B.H. J. Exp. Med. 128:1267, 1968.
Aggarwal, B.B., Henzel, W.J., Moffat, B., Kohr, W.J. and Harkins, R.N. J. Biol. Chem. 260:2334, 1985.
Spies, T., Morton, C.C., Nedospasov, S.A., Fiers, W., Pious, D. and Strominger, J.L. Proc. Natl. Acad. Sci. USA 83:8699, 1986.
Muller, U., Jongeneel, C.V., Nedospasov, S.A., Lindahl, K.F. and Steinmetz, M. Nature 325:265, 1987.
Beutler, B., Greenwald, D., Hulmes, J.D., Chang, M., Pan, Y.-C. E., Mathison, J., Ulevitch, R. and Cerami, A. Nature 316:552, 1985.
Beutler, B.A. and Cerami, A. Nature 320:584, 1986.
Le, J. and Vilček, J. Lab. Invest. 56:234, 1987.
Sugarman, B.J., Aggarwal, B.B., Hass, P.E., Figari, I.S., Palladino, M.A. and Shepard, H.M. Science 230:943, 1985.
Vilček, J., Palombella, V.J., Henriksen-DeStefano, D., Swenson, C, Feinman, R., Hirai, M. and Tsujimoto, M. J. Exp. Med. 163:632, 1985.
Tsujimoto, M., Yip, Y.K. and Vilček, J. J. Immunol. 136:2441, 1986.
Aggarwal, B.B., Eessalu, T.E. and Hass, P.E. Nature 318:665, 1985.
Nitsu, Y., Watanabe, N., Sone, H., Neda, H., Yamauchi, N. and Urushizaki, I. Jpn. J. Cancer Res. 76:1193, 1985.
Old, L.J. Nature 326:330, 1987.
Ruddle, N.A. Immunol. Today 6:156, 1985.
Hahn, T., Toker, L., Budilovsky, S., Aderka, D., Eshhar, Z. and Wallach, D. Proc. Natl. Acad. Sci. USA 82:3814, 1985.
Matthews, N. and Watkins, J.F. Br. J. Cancer 38:302, 1978.
Ruff, M.R. and Gifford, G.E. In: Lymphokines, Vol. 2 (ed. E. Pick), Academic Press, New York, 1981, pp235–272.
Matthews, N. Br. J. Cancer 44:405, 1983.
Tsujimoto, M., Yip, Y.K. and Vilček, J. Proc. Natl. Acad. Sci. USA 82:7626, 1985.
Feinman, R., Henriksen-DeStefano, D., Tsujimoto, M., and Vilček, J. J. Immunol. 138:635, 1987.
Kirstein, M. and Baglioni, C. J. Biol. Chem. 261:9565, 1986.
Rosenau, W., Goldberg, M.L. and Burke, G.C. J. Immunol. 111:1128, 1973.
Lee, S.H., Aggarwal, B.B., Rinderknecht, E., Assisi, F. and Chiu, H. J. Immunol. 133:1083, 1984.
Darzynkiewicz, Z., Williamson, B., Carswell, E.A. and Old, L.J. Cancer Res. 44:83, 1984.
Trinchieri, G., Kobayashi, M., Rosen, M., Loudon, R., Murphy, M. and Perussia, B. J.Exp. Med. 164:1206, 1986.
Sugarman, B.J., Lewis G.D., Eessalu, T.E., Aggarwal, B.B., Shepard, H.M. Cancer Res. 47:780, 1987.
Haranaka, K., Satomi, N. and Sakurai, A. Int. J. Cancer 34:263, 1984.
Palladino JR., M.A., Shalaby, M.R., Kramer, S.M., Ferraiolo, B.L., Baughman, R.A., Deleo, A.B., Crase, D., Marafino, B., Aggarwal, B.B., Figari, I.S., Liggit, D. and Patton, J.S. J. Immunol. 138:4023, 1987.
Gresser, I., Belardelli, F., Tavernier, J., Fiers, W., Podo, F., Federico, M., Carpinelli, G., Duvillard, P., Prade, M., Maury, C, Bandu, M.-T. and Maunoury, M.-T. Int. J. Cancer 38:771, 1986.
Asher, A., Mule, J.J., Reichert, C.M., Shiloni, E. and Rosenberg, S.A. J. Immunol. 138:963, 1987.
Williamson, B.D., Carswell., E.A., Rubin, B.Y., Prendergast, J.S. and Old, L.J. Proc. Natl. Acad. Sci. USA 80:5397, 1983.
Fransen, L., Van Der Heyden, J., Ruysschaert, R. and Fiers, W. Eur. J. Cancer Clin. Oncol. 22:419, 1986.
Schiller, J.H., Bittner, G., Storer, B. and Willson, J.K.V. Cancer Res. 47:2809, 1987.
Scheurich, P., Ucer, U., Kronke, M. and Pfizenmaier, K. Int. J. Cancer 38:127, 1986.
Williams, T.W., Bellanti, J.A. J. Immunol. 130:518, 1983.
Stone-Wolff, D.S., Yip, Y.K., Kelker, H.C., Le, J., Henriksen-DeStefano, D., Rubin, B., Rinderknecht, E., Aggarwal, B.B., Vilček, J. J. Exp. Med. 159:828, 1984.
Ruggiero, V., Tavernier, J., Fiers, W. and Baglioni, C. J. Immunol. 136:2445, 1986.
Tsujimoto, M., Vilček, J. J. Biol. Chem. 261:5384, 1986.
Tsujimoto, M., Feinman, R., Vilček, J. J. Immunol. 137:2272, 1986.
Yarden, A. and Kimchi, A. Science 234:1419, 1986.
Balkwill, F.R., Lee, A., Aldam, G., Moodie, E., Thomas, J.E., Tavernier, J. and Fiers, W. 1986. Cancer Res. 46:3990, 1986.
Brouckaert, P.G.G., Leroux-Roels, G.G., Guisez, Y., Tavernier, J. and Fiers, W. Int. J. Cancer 38:763, 1986.
In: AmFAR Directory of Experimental Treatments for AIDS and ARC, Vol. 1 (Eds. M. Gottlieb, M. Grieco, L.N. Painter, and S. Bernstein) Mary Ann Liebert, Inc., New York, 1987, p. 86.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Kluwer Academic Publishers, Boston
About this chapter
Cite this chapter
Feinman, R., Vilček, J. (1988). Synergistic Actions of Interferons and Tumor Necrosis Factor. In: Revel, M. (eds) Clinical Aspects of Interferons. Developments in Medical Virology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1737-1_27
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1737-1_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8977-7
Online ISBN: 978-1-4613-1737-1
eBook Packages: Springer Book Archive