Abstract
The growth of scientific knowledge on interferons (IFN) has been accelerated by hybridoma and recombinant DNA technologies. In the past, among many biological effects of IFNs, anti-viral and anti-tumor activities received much attention and only recently have publications started to accumulate emphasizing the immunoregulating abilities of IFNs. While we refer the reader to earlier extensive reviews (1–4) in this short review we wish to summarize very recent data which deal with the effect of IFNs on various immunocytes with a special emphasis on IFNγ. The immune system which has evolved to protect the individual from infectious agents has to solve four major problems: The first is to discriminate self from non-self. The second is to mount a proper class of immune response so that different kinds of antigens can be efficiently eliminated. The third is regulation and orchestration of its own responses. The fourth is the generation of diversity in order to recognize an almost infinite number of antigens (each specifically). Available evidence indicate that IFNs influence the immune system in solving the first three problems. Here the T lymphocytes seem to be crucial cells, because they can help or suppress the functions of other lymphocytes. It is known that T cells can only recognize foreign antigens in association with self-antigens whose expression is regulated by IFNs.
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References
Schultz, R.M. Lymphokine Rep. 1 63–97, 1980.
Friedman, R.M. and Vogel. S.N. in: Advances in Immunology (eds. Dixon F.J., and Kunkel, H.G), pp. 97–140, Academic Pres, N.York, London 1983.
Trinchieri, G. and Perussia, B. Immunology Today 6 131–136, (1985)
DeMaeyer-Guignard, J. and DeMaeyer, E. Interferon (London) 6: 69–91, 1985.
Belardelli, F., Vignaux, F., Proietti, E. and Gresser, I. Proc. Natl. Acad. Sci. USA 81:602–606, 1984.
Gresser, I., Belardelli, F., Maury, Ch., Maunoury, M.-T. and Tovey, M.G. J. Exp. Med. 158:2095–2107, 1983.
Varesio, L., Blasi, E., Thurman, G.B., Talmadge, J.E., Wiltrout, R.H and Herberman, R.B. Cancer Res. 44:4465–4469, 1984.
Nathan, C.F., Prendergast, Th.J., Wiebe, M.E., Stanley, E.R., Platzer, E., Remold, H.G., Weite, K., Rubin, B.Y. and Murray, H.Y. J. Exp. Med. 160:600–605, 1984.
Celada, A., Gray, P.W., Rinderknecht, E. and Schreiber R.D. J. Exp. Med. 160:55–74, 1984.
Peters, P.M., Svedersky, L.P., Shalaby, M.R. and Palladino, jr. M.A. Lymphokine Res., 4:265–273, 1985.
Murray, H.W., Spitalny, G.L. and Nathan, CF. J. Immunol. 134: 1619–1622, 1985.
Arenzana-Seisdedos, F.A., Virelizier, J.L. and Fiers, W.J. Immunol. 134:2444–2448, 1985.
Rollag, H. and Sonnenfeld, G. Scand. J. Immunol. 20:149–155. (1984)
Rollag, H. and Degré, M. Acta Pathol. Microbiol. Scand. Sect. B, 89:153, 1981.
Degré, M., Rollag, H., Melby, K., Midtredt, T., Morland, B., Sonnenfeld, G. and DeLey, M. In: The Biology of the Interferon System (DeMaeyer, E., Galasso, G. and Schellekens, H. eds.); Elsevier North-Holland, New York, page 161, 1981.
Wang, E., Michl, J., Pfeffer, L., Silverstein, S., and Tamm, I. J. Cell Biol. 91:238 a (Abstract 13026), 1981.
Perussia, B., Dayton, E.T., Lazarus, R., Fanning, V. and Trinchieri, G. J. Exp. Med. 158:1092–1113, 1983.
Vogel, S.N., English, K.E., Fertsch, D. and Fultz, M.J. J. Interferon Res. 3:153, 1983 a.
Vogel, S.N., Finbloom, D.S., English, K.E., Rosenstreich, D.L. and Langreth, S.G. J. Immunol. 130:1210, 1983 b.
Fertsch, D. and Vogel, S.N. J. Immunol. 112:2436–2439, 1984.
Hokeland, P. and Berg, K. J. Immunol. 127:1585–1588, 1981.
Lang, N.P., Ortaldo, J.R., Bonnard, G.D. and Herbermann, R.B. J. Natl. Cancer Res. Inst. 69:339–343, 1982.
Akiyama, Y., Lubeck, M.D., Steplewski, Z. and Koprowski, H. Cancer Res. 44:5127–5131, 1984.
Gergely, Y. 7th European Immunology meeting of E.F.I.S., Jerusalem, Abstract S03, p. 35, 1985.
Akagacsa, K. and Tokunaga, T. J. Exp. Med. 162:1444–1459, 1985.
Baraschi, D., Censini, St. and Tagliabue, A. J. Immunol. 133:764–767, 1984.
Mizel, S.B. Immunol. Rev. 63:51–72, 1982.
Zubler, R.H., Löwenthal, J.W., Erard, F., Hashimoto, N., Devos, R. and MacDonald, H.R. J. Exp. Med. 160: 1170–1183, 1984.
Bettens, F., Kristensen, F., Walker, C, Bonnard, G.D. and DeWeck, A.L. Cell. Immunol. 86:337–346, 1984.
Bismuth, G., Leclercq, L., Duphot, M., Moreau, J.L. and Theze, J. Cell. Immunol. 86:90–100, 1984.
Reem, G. and Yeh, N. J. Immunol. 134:953–958, 1985.
Vilcek, J., Henriksen-Destefano, D., Siegel, D., Klion, A., Robb, R.J. and Le J. J. Immunol. 135:1851–1856, 1985.
Croll, A.D., Wilkinson, M.F. and Morris, A.G. Cell. Immunol. 92: 184–189, 1985.
Jones, C.M., Varesio, L., Herbermann, R.B. and Pestka, S. J. Interferon Res. 2:377–386, 1982.
Svedersky, L.P., Nedwin, G.E., Goeddel, D.V. and Palladino, M.A. J. Immunol., in press, 1985.
Klimpel, G.R., Fleischmann, W.R. and Klimpel, K.D. J. Immunol. 129: 76, 1982.
Fellous, M., Nir, U., Wallach, D., Merlin, G., Rubinstein, M. and Revel, M. Proc. Natl. Acad. Sci. USA, 79:3082–3086, 1982.
Houghton, A.N., Tomson, T.M., Gross, D., Oettgen, H.F. and Old, L.J. J. Exp. Med. 160:255–269, 1984.
Ball, E.D. Guyre, P.M., Glynn, J.M. Rigby, W.F.C., and Fanger, M.W. J. Immunol. 132:2424–2428, 1984.
Ozato, K., Wan, Y.J. and Orrison, B.M. Proc. Natl. Acad. Sci. USA, 82:2427–2431, 1985.
Basham, T. and Merigan, Th. J. Immunol. 130:1492–1494, 1983.
King, D.P. and Jones, P.P. J. Immunol. 131:315–318, 1983.
Kelley, V.E., Fiers, W. and Strom, T.B. J. Immunol. 132:240–245, 1984.
Sztein, M.B., Steeg, P.S., Johnson, H.M. and Oppenheim, J.J. J. Clin. Invest. 73:556–565, 1984.
Koch, N., Wong, G.H. and Schrader, J.W. J. Immunol. 132:1361–1368, 1984.
Becker, S. Cell. Immunol. 91:301–307, 1985.
Capobianchi, M.R., Ameglio, F., Tosi, R. and Dolei, A. Human Immunol. 13:1–11, 1985.
Ling, P.D., Warren, M.K. and Vogel, S. J. Immunol. 135:1857–1863, 1985.
Ameglio, F., Capobianchi, M.R., Dolei, A. and Josi, R. Infect. Immun. 42:122–125, 1983.
Houghton, A.N., Johnson, T.M., Gross, D., Oettgen, H.F. and Old, L.J. J. Exp. Med. 160:255–269, 1984.
Schwartz, R., Momburg, F., Moldehauer, G., Dörken, B. and Schirrmacher, V. Int. J. Cancer 35:245–250, 1985.
Carrel, S., Schmidt-Kessen, A. and Giuffré, L. Eur. J. Immunol. 15:118–123, 1985.
Anböck, J., Niederwieser, D., Romani, N., Fritsch, P. and Huber, C. Arch. Dermatol. Res. 277:270–275, 1985.
Berrih, S., Arenzana, Seisdedos, F., Cohen, S., Devos, R., Charron, D. and Virelizier, J.-L. J. Immunol. 135:1165–1171, 1985.
Weigent, D.A., Langford, M.P., Fleischmann, W.R.jr. and Stanton, G.J. In: Human Lymphokines (Khan, A. and Hill, N.O. eds.), pp. 539–550, Academic Press, New York and London, 1982.
Herberman, R.B., Ortaldo, J.R., Mantovani, A., Hobbs, D.S., Kung, H.F. and Pestka, S. Cell. Immunol. 67:160–167, 1982.
Kirchner, H. Progress Clin. Biochem. and Med. 1 192–193, 1984.
Degliantoni, G., Murphy, M., Kobayashi, M., Francis, M.K., Perussia, B. and Trinchieri, G. J.Exp. Med. 162:1512–1530, 1985.
Zoumbos, N.C., Gascon, P., Dijeu, J.Y. and Young, N.S. Proc. Natl. Acad. Sci. USA 82:188–192, 1985.
Adam, C, Thoua, Y., Ronco, P., Verroust, P. and Tovey, M. Clin. exp. Immunol. 40:373–382, 1980.
Nakamura, M., Manser, T., Pearson, G.D.N., Daley, M.J. and Gefter, M.L. Nature (London) 307:381–382, 1984.
Leibson, H.J., Gefter, M., Zlotnik, A., Marrak, Ph. and Kappler, J.W. Nature (London) 309:799–801, 1984.
Sidman, C.L., Marshall, J.D., Shultz, L.D., Gray, P.W. and Johnson, H.M. Nature (London) 309:801–803, 1984.
Falcoff, R.J.M., Butler, J.L., Dinarello, C.A. and Fauci, A.S. J. Immunol. 133:692–696, 1984.
Nakagawa, T., Hirano, T., Nakagawa, N., Yoshizaki, K. and Kishimoto, T. J. Immunol. 134:959–966, 1985.
Murray, P.D., Swain, S.L. and Kagnoff, M.F. Fed. Proc. 44:1293 (Abstract), 1985.
Shalaby, M.R., Week, P.K., Rinderknecht, E., Harkins, R.N., Frane, J.W. and Ross, M.J. Cell. Immunol. 84:380–392, 1984.
Pelton, B.K. and Denman, A.M. Clin. exp. Immunol. 59:398–404, 1985.
Aune, T.M. Int. J. Immunopharmac. 7:65–71, 1985.
Neubauer, R.H., Goldstein, L., Rabin, H. and Stebbing, N. J. Immunol. 134:299–304, 1985.
Gisler, R.H., Lindahl, P. and Gresser, I. J. Immunol. 113:438–444, 1974.
Frasca, D., Adorini, L., Landolfo, S. and Doria, G. J. Immunol. 134:3907–3911, 1985.
Alkan, S.S., Miescher-Granger, S., Braun, D.G. and Hochkeppel, H.K. J. Interferon R. 4:355–363, 1984.
Grob, P.J., Joller-Jemelka, H.I., Binswanger, K., Zaruba, K., Descoeudres, C. and Fernex, M. Eur. J. Clin. Microbiol. 3:195–198, 1984.
Skoskiewicz, M.J., Coloin, R.B., Schneeberger, E.E. and Russell, P.S. J. Exp. Med. 162:1645–1664, 1985.
Bhayani, H. and Hudson, L. J. Interferon Res. 4:41–50, 1984.
Vitetta, E.S., Ohara, J., Myers, C, Layton, J., Krammer, P.H., and Paul, W.E. J. Exp. Med. 162:1726–1731, 1985.
Ling, P.D., Warren, M.K. and Vogel, S.N. J. Immunol. 135:1857–63, 1985.
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© 1988 Kluwer Academic Publishers, Boston
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Hochkeppel, H.K., Alkan, S.S. (1988). Immunomodulatory Actions of Interferons. In: Revel, M. (eds) Clinical Aspects of Interferons. Developments in Medical Virology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1737-1_26
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DOI: https://doi.org/10.1007/978-1-4613-1737-1_26
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