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Immunomodulatory Actions of Interferons

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Book cover Clinical Aspects of Interferons

Part of the book series: Developments in Medical Virology ((DIMV,volume 4))

Abstract

The growth of scientific knowledge on interferons (IFN) has been accelerated by hybridoma and recombinant DNA technologies. In the past, among many biological effects of IFNs, anti-viral and anti-tumor activities received much attention and only recently have publications started to accumulate emphasizing the immunoregulating abilities of IFNs. While we refer the reader to earlier extensive reviews (1–4) in this short review we wish to summarize very recent data which deal with the effect of IFNs on various immunocytes with a special emphasis on IFNγ. The immune system which has evolved to protect the individual from infectious agents has to solve four major problems: The first is to discriminate self from non-self. The second is to mount a proper class of immune response so that different kinds of antigens can be efficiently eliminated. The third is regulation and orchestration of its own responses. The fourth is the generation of diversity in order to recognize an almost infinite number of antigens (each specifically). Available evidence indicate that IFNs influence the immune system in solving the first three problems. Here the T lymphocytes seem to be crucial cells, because they can help or suppress the functions of other lymphocytes. It is known that T cells can only recognize foreign antigens in association with self-antigens whose expression is regulated by IFNs.

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  1. Ciba-Geigy Ltd, CH-4002, Basel, Switzerland

    H. K. Hochkeppel & S. S. Alkan

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  1. H. K. Hochkeppel
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  2. S. S. Alkan
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  1. The Weizmann Institute of Science, Israel

    Michel Revel

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© 1988 Kluwer Academic Publishers, Boston

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Hochkeppel, H.K., Alkan, S.S. (1988). Immunomodulatory Actions of Interferons. In: Revel, M. (eds) Clinical Aspects of Interferons. Developments in Medical Virology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1737-1_26

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  • DOI: https://doi.org/10.1007/978-1-4613-1737-1_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8977-7

  • Online ISBN: 978-1-4613-1737-1

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