Abstract
Insulin-dependent diabetes mellitus ranks as one of the major disease entities in the world. Six hundred thousand new patients are diagnosed each year in the United States. Prior to the introduction of insulin, the life expectancy of diabetic patients was about two years from the time of diagnosis. In spite of insulin therapy, the morbidity resulting from microangiopathy still exists. The National Commission on Diabetes in the United States has reported that insulin-dependent diabetes mellitus patients are 25 times more prone to blindness, 17 times more prone to renal disease, five times more afflicted with gangrene, and twice as often exposed to heart disease and stroke than nondiabetic individuals. Diabetes mellitus is the cause of 260,000 deaths annually and has a health care cost of $18 billion.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Jacobs C, Lerner FP, Brynger H: Diabetic Nephropathy 2:12–17, 1983.
Gonzallez-Carrillo M, Moloney A, Bewick M, Parsons V: Renal transplantation in diabetic nephropathy. Br Med J 285:1713–1716, 1982.
Brink SJ, Stewart C: Insulin pump treatment in insulin-dependent diabetes mellitus children, adolescents and young adults. JAMA 255:617–621, 1986.
Lee CS, Mauer SM, Brown DM, Sutherland DER, Michael AF, Najarian JS: Renal transplantation in diabetes mellitus in rats. J Exp Med 139:793–797, 1974.
Abouna GM, Al Adnani MS, Kremer GD, Kumar SA, Daddah SK, Kusma G: Reversal of diabetic nephropathy in human cadaveric kidneys after transplantation into nondiabetic recipients. Lancet 3:1276, 1983.
Groth CG, Lundgren G, Ostman J, Gunnarson R: Experience with nine segmental pancreatic transplantation in three uremic diabetic patients in Stockholm. Transplant Proc 12:68–72, 1980.
Sutherland DER, Goetz FC, Carpenter AM, Najarian JS, Lillehei RC: Pancreaticoduodenal graft: Clinical and pathologic observation in uremic versus nonuremic recipients. Transplant Clin Immunol 10:190–195, 1978.
Gliedman ML, Tellis VA, Soberman R, Rifkin H, Veith FJ: Long term effects of pancreatic transplant function in patients with advanced juvenile diabetes: Diabetes Care 1:1–9, 1978.
Sutherland DER, Goetz FC, Kendall DM, Najarian JS: One institution’s experience with pancreas transplantation. Wes J Med 14: 838–844, 1985.
Rosenbloom AL, Silverstein JH, Lezotte DC, Richardson K, McCallum M: Limited joint mobility in childhood diabetes mellitus indicates increased risk for microvascular disease. N Engl J Med 305:191–194, 1981.
Merimee TJ, Zapf J, Foresch ER: Insulinlike growth factors: Studies in diabetics with and without retinopathy. N Engl J Med 309:527–530, 1983.
White NH, Skor DA, Cryer PE, Levandoski LA, Bier DM, Santiago JV: Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 308:485–481, 1983.
Joint Scandanavian Report. Lancet 2:915–920, 1978.
Nghiem DD, Schulak JA, Corry RJ: Duode-nopancreatectomy for transplantation. Arch Surg 122:1201–1206, 1987.
Corry RJ, Nghiem DD, Schulak JA, Gonwa TA: Surgical treatment of diabetic nephropathy with simultaneous pancreatic, duodenal and renal transplantation. Surg Gynecol Obstet 162:547–555, 1986.
Skandalakis JE, Gray JW, Rowe JS, Skandalakis LJ: Anatomical complications of pancreatic surgery. Contemp Surg 11:17–40, 1979.
Groth CG: Clinical pancreatic transplantation. Transplant Proc 17:302–306, 1985.
Nghiem DD, Pitzen RH, Corry RJ: Evaluation of techniques for controlling exocrine drainage after segmental pancreatectomy in dogs: Implications for pancreatic transplantation. Arch Surg 120:1132–1137, 1985.
Starzl TE, Iwatsuki S, Shaw DW: Pancreaticoduodenal transplantation in human. Surg Gynecol Obstet 159:265–272, 1984.
Gonwa TA, Goeken NE, Schulak JA, Nghiem DD, Corry RJ. Failure of cyclosporine to prevent In vivo T-cell priming in man: Studies in allogeneic spleen transplantation. Transplantation 40:299–304, 1985.
Calne RY, McMaster P, Rolles K, Duffy TJ: Technical observations in segmental pancreas allografting: Observations on pancreatic blood flow. Transplant Proc 12:51–57, 1980.
Badosa F, Bannett G, Lindenbaum A, Baquero: Arterial electromagnetic flow measurements in total canine pancreatic allografts with distal splenocaval arteriovenous fistula (AVF); Abstract Books; Annual Meeting of the Association for Academic Surgery, Cincinnati, Ohio, November 10–14, 1985.
Sells RA, Millar RJ, Williamson EPM, Lear PA: A successful technique for segmental pancreatic transplantation. Proceedings of 11th International Congress of the Transplantation Society, Helsinki, Finland, August 3–8, 1986.
Schulak JA, Drevyanko T, Englestad K: Diagnosis and treatment of experimental pancreatic allograft rejection. Transplant Proc 17:372–373, 1985.
Nghiem DD, Gonwa TA, Corry RJ: Metabolic effects of urinary diversion of exocrine secretions in pancreatic transplantation. Transplantation 43:70–73, 1987.
Sollinger HW, Kalayoglu M, Hoffmann RM, Deierhoi MH, Beizer FO: Quadruple immunosuppressive therapy in whole pancreas transplantation. Transplant Proc 19:2297–2299,1987.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Kluwer Academic Publishers
About this chapter
Cite this chapter
Nghiem, D.D., Corry, R.J. (1988). Bowel-Drained Pancreas Transplants. In: Toledo-Pereyra, L.H. (eds) Pancreas Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1735-7_15
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1735-7_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8976-0
Online ISBN: 978-1-4613-1735-7
eBook Packages: Springer Book Archive