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Heterogeneity of genetic alterations in primary human breast tumors

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Breast Cancer: Cellular and Molecular Biology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 40))

Abstract

The etiology of human breast cancer is thought to involve a complex interplay among genetic, hormonal, and dietary factors that are superimposed on the physiological status of the host [1, 2]. As a consequence, several different types of breast tumors can be distinguished by histopathological criteria, chromosomal abnormalities, hormone receptor status, and other biochemical characteristics. However, attempts to derive a cohesive picture of how the various factors participate in the etiology of breast cancer have been confounded by a lack of information on specific genetic mutations associated with the initiation or progression of the disease. Three general approaches have been used to attempt to identify genetic mutations associated with breast cancer.

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Authors
  1. Iqbal Unnisa Ali
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  2. Rosette Lidereau
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  3. Robert Callahan
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Editors and Affiliations

  1. National Cancer Institute, USA

    Marc E. Lippman  & Robert B. Dickson  & 

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© 1988 Kluwer Academic Publishers, Boston/Dordrecht/London

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Ali, I.U., Lidereau, R., Callahan, R. (1988). Heterogeneity of genetic alterations in primary human breast tumors. In: Lippman, M.E., Dickson, R.B. (eds) Breast Cancer: Cellular and Molecular Biology. Cancer Treatment and Research, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1733-3_2

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  • DOI: https://doi.org/10.1007/978-1-4613-1733-3_2

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