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Endocrine Therapies in Breast and Prostate Cancer pp 111–129Cite as

Effects of Estrogens and Antiestrogens on Cell Proliferation

Implications for the Treatment of Breast Cancer

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 39))

Abstract

It has been recognized for many years that breast cancer in some women is regulated in part by the female sex steroid hormone estrogen. About one-third of human breast carcinomas are ‘hormone-dependent’ and respond to various endocrine manipulations, which are usually designed to block the stimulatory effects of estrogen on tumor growth. Although the mechanisms by which additive hormone therapies, such as pharmacologic estrogens or progestins, inhibit tumor growth have not been defined, treatment by oophorectomy, adrenalectomy, hypophysectomy, luteinizing hormone-releasing hormone (LHRH) super agonists, and aromatase inhibitors such as amino-glutethimide presumably inhibit growth by reducing the concentration of estrogen available to the cancer cell. The nonsteroidal antiestrogens block the effects of endogenous estrogen at the cancer cell itself by competing with estrogen for its receptor.

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Authors
  1. C. Kent Osborne
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Editors and Affiliations

  1. Department of Medicine, Division of Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

    C. Kent Osborne

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© 1988 Kluwer Academic Publishers, Boston

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Osborne, C.K. (1988). Effects of Estrogens and Antiestrogens on Cell Proliferation. In: Osborne, C.K. (eds) Endocrine Therapies in Breast and Prostate Cancer. Cancer Treatment and Research, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1731-9_8

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  • DOI: https://doi.org/10.1007/978-1-4613-1731-9_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8974-6

  • Online ISBN: 978-1-4613-1731-9

  • eBook Packages: Springer Book Archive

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