Effects of Estrogens and Antiestrogens on Cell Proliferation
It has been recognized for many years that breast cancer in some women is regulated in part by the female sex steroid hormone estrogen. About one-third of human breast carcinomas are ‘hormone-dependent’ and respond to various endocrine manipulations, which are usually designed to block the stimulatory effects of estrogen on tumor growth. Although the mechanisms by which additive hormone therapies, such as pharmacologic estrogens or progestins, inhibit tumor growth have not been defined, treatment by oophorectomy, adrenalectomy, hypophysectomy, luteinizing hormone-releasing hormone (LHRH) super agonists, and aromatase inhibitors such as amino-glutethimide presumably inhibit growth by reducing the concentration of estrogen available to the cancer cell. The nonsteroidal antiestrogens block the effects of endogenous estrogen at the cancer cell itself by competing with estrogen for its receptor.
KeywordsBreast Cancer Breast Cancer Cell Human Breast Cancer Cell Human Breast Cancer Cell Line Athymic Nude Mouse
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