Effect of Ultraviolet Radiation on Eicosanoid Metabolism of Cells in Culture
Solar ultraviolet radiation (UV) is a ubiquitous environmental agent known to produce numerous effects in human skin. These effects Include inflammation, pigmentation, carcinogenesis, local and systemic immune suppression, aging and Vitamin D metabolism. In addition, such radiation can produce cutaneous disease in individuals rendered abnormally photosensitive by the presence of exogenous drugs and chemicals or endogenous substances such as porphyrins. The mechanisms by which such radiation evokes most of these cutaneous photobiological effects have been studied in some detail but the responses remain poorly understood.
KeywordsLipase Histamine Dexamethasone Prostaglandin Porphyrin
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