Schwann Cell Contact as a Factor in Neuronal Trophic Support and the Promotion of Neurite Growth

  • R. P. Bunge
  • C. F. Eldridge
  • M. D. Ard
  • N. Kleitman
Part of the Topics in the Neurosciences book series (TINS, volume 8)

Abstract

During development, and in the adult organism, neurons are provided with factors from their environment that influence their survival and growth. The best known factor influencing neuronal survival, nerve growth factor (NGF), is a low molecular weight peptide that is believed to be released in minute amounts in regions innervated by specific neuronal types, taken up via receptors on the neuronal processes, and transported via axoplasmic transport to the neuronal perikaryon [1], The limited amount of material thought to be available in target regions and the competition for this essential survival factor is considered a critical determinant of neuronal cell death during embryogenesis. This mechanism of growth factor release and uptake is generally considered a model for the action of trophic factors for other neuronal types as well [2]. Factors influencing neuronal process growth are legion; recently, particular emphasis has been placed on the efficacy of extracellular matrix materials in promoting rapid and profuse neurite growth from neurons of several types [3, 4].

Keywords

Retina Posit Peri Fibril Stein 

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References

  1. 1.
    Thoenen, H. and Barde, Y. (1980). Physiology of nerve growth factor. Physiol. Inv. 60, 1284–1335.Google Scholar
  2. 2.
    Barde, Y.-A., Davies, A.M., Johnson, J.E., Lindsay, R.M. and Thoenen, H. (1987). Brain derived neurotrophic factor. In Proceedings of the International Symposium on Neural Regeneration, Progress in Brain Research, Vol. 71, F.J. Seil, E. Herbert, B.M. Carlson, eds., Elsevier, pp. 185–190.CrossRefGoogle Scholar
  3. 3.
    Chiu, A.Y., Matthew, W.D. and Patterson, P.H. (1986). A monoclonal antibody that blocks the activity of a neurite regeneration-promoting factor: Studies on the binding site and its localization in vivo. J. Cell Biol. 103, 1383–1398.PubMedCrossRefGoogle Scholar
  4. 4.
    Davis, G.E., Varon, S., Engvall, E. and Manthorpe, M. (1985). Substratum-binding neurite-promoting factors: Relationships to laminin. Trends in Neurosci. 8, 528–532.CrossRefGoogle Scholar
  5. 5.
    Eldridge, C.F. and Bunge, R.P. (1987). Schwann cell-axon contact as a mechanism of neuronal trophic support, in preparation.Google Scholar
  6. 6.
    Ard, M.D., Bunge, R.P. and Bunge, M.B. (1987). Comparison of the Schwann cell surface and Schwann cell extracellular matrix as promoters of neurite growth. J. Neurocytol. 16, 539–555.PubMedCrossRefGoogle Scholar
  7. 7.
    Kleitman, N., Wood, P., Johnson, M.I. and Bunge, R.P. (1988). Schwann cell surfaces but not extracellular matrix support neurite outgrowth from cultured embryonic rat retina. J. Neurosci. 8, 653–663.PubMedGoogle Scholar
  8. 8.
    Wood, P.M. (1976). Separation of functional Schwann cells and neurons from normal peripheral nerve tissue. Brain Res. 115, 361–375.PubMedCrossRefGoogle Scholar
  9. 9.
    Eldridge, C.F., Bunge, M.B. and Bunge, R.P. (1987). Differentiation of axon-related Schwann cells in vitro. I. Ascorbic acid regulates basal lamina assembly and myelin formation. J. Cell Biol. 105, 1023–1034.PubMedCrossRefGoogle Scholar
  10. 10.
    Brockes, J.P., Fields, K.L. and Raff, M.C. (1979). Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve. Brain Res. 165, 105–118.PubMedCrossRefGoogle Scholar
  11. 11.
    Moya, F., Bunge, R.P. and Bunge, M.B. (1980). Schwann cells proliferate but fail to differentiate in defined medium. Proc. Natl. Acad. Sci. USA 77, 6902–6906.PubMedCrossRefGoogle Scholar
  12. 12.
    Bottenstein, J.E. and Sato, G.H. (1979). Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl. Acad. Sci. USA 76, 514–517.PubMedCrossRefGoogle Scholar
  13. 13.
    Taniuchi, M., Clark, H.B. and Johnson, E.M. (1986). Induction of nerve growth factor receptor In Schwann cells after axotomy. Proc. Natl. Acad. Sci. USA 83, 4094–4098.PubMedCrossRefGoogle Scholar
  14. 14.
    Waxman, S.G. and Ritchie, J.M. (1985). Organization of ion channels in the myelinated nerve fibers. Science 228, 1502–1507.PubMedCrossRefGoogle Scholar
  15. 15.
    Barde, Y.-A., Edgar, D. and Thoenen, H. (1980). Sensory neurons in culture: Changing requirements for survival factors during embryonic development. Proc. Natl. Acad. Sci. USA 77, 1119.CrossRefGoogle Scholar
  16. 16.
    Scherer, S.S. and Easter, S.S. (1984). Degenerative and regenerative changes in the trochlear nerve of goldfish. J. Neurocytol. 13, 519–565.PubMedCrossRefGoogle Scholar
  17. 17.
    Ide, C., Tohyama, K., Yokota, R., Nitatori, T. and Onodera, S. (1983). Schwann cell basal lamina and nerve regeneration. Brain Res. 288, 61–75.PubMedCrossRefGoogle Scholar
  18. 18.
    Hall, S.M. (1986). Regeneration in cellular and acellular autografts in the peripheral nervous system. Neuropath. Appl. Neurobiol. 12, 27–46.CrossRefGoogle Scholar
  19. 19.
    Cornbrooks, C.J., Carey, D.J., McDonald, J. A., Timpl, R. and Bunge, R.P. (1983). In vivo and in vitro observations on laminin production by Schwann cells. Proc. Natl. Acad. Sci. USA 80, 3850–3854.PubMedCrossRefGoogle Scholar
  20. 20.
    Tomaselli, K.J., Reichardt, L.F. and Bixby, J.L. (1986). Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices. J. Cell Biol. 103, 2659–2672.PubMedCrossRefGoogle Scholar
  21. 21.
    Kleitman, N. and Johnson, M.I. (1986). Olfactory bulb neurite extension in cultures is age and substrate dependent. Soc. Neurosci. Abstr. 12, 1112.Google Scholar
  22. 22.
    Manthorpe, M., Engvall, E., Ruoslahti, E., Longo, F.M., Davis, G.E. and Varon, S. (1983). Laminin promotes neuritic regeneration from cultured peripheral and central neurons. J. Cell Biol. 97, 1882–1890.PubMedCrossRefGoogle Scholar
  23. 23.
    Rogers, S.L., Letourneau, P.C., Palm, S.L., McCarthy, J. and Furcht, L.T. (1983), Neurite extension by peripheral and central nervous system neurons in response to substratum-bound fibronectin and laminin. Dev. Biol. 98, 212–220.PubMedCrossRefGoogle Scholar
  24. 24.
    Adler, R., Jerdan, J. and Hewitt, A.T. (1985). Responses of cultured neural retinal cells to substratum-bound laminin and other extracellular matrix molecules. Dev. Biol. 112, 100–114.PubMedCrossRefGoogle Scholar
  25. 25.
    So, K.-F. and Aguayo, A.J. (1985). Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retinal of adult rats. Brain Res. 328, 349–354.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • R. P. Bunge
  • C. F. Eldridge
  • M. D. Ard
  • N. Kleitman

There are no affiliations available

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