Schwann Cell Contact as a Factor in Neuronal Trophic Support and the Promotion of Neurite Growth
During development, and in the adult organism, neurons are provided with factors from their environment that influence their survival and growth. The best known factor influencing neuronal survival, nerve growth factor (NGF), is a low molecular weight peptide that is believed to be released in minute amounts in regions innervated by specific neuronal types, taken up via receptors on the neuronal processes, and transported via axoplasmic transport to the neuronal perikaryon , The limited amount of material thought to be available in target regions and the competition for this essential survival factor is considered a critical determinant of neuronal cell death during embryogenesis. This mechanism of growth factor release and uptake is generally considered a model for the action of trophic factors for other neuronal types as well . Factors influencing neuronal process growth are legion; recently, particular emphasis has been placed on the efficacy of extracellular matrix materials in promoting rapid and profuse neurite growth from neurons of several types [3, 4].
KeywordsNerve Growth Factor Schwann Cell Neurite Growth Basal Lamina Retinal Ganglion Cell
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