Abstract
Kidney bean lectin (PHA-L) was used as an anterograde axonal tracer to label fibers from the magnocellular areas of the basal forebrain (especially the ventral pallidum and other parts of the substantia innominata). Previous studies have reported that cells in these regions provide input to all nonstriatal parts of the telencephalon, including the cerebral cortex, amygdaloid complex, hippo-campal formation, and olfactory bulb and cortex [1–5]. Notably, a high proportion of the fibers to the neocortex has been reported to be cholinergic [4].
Supported by NIH grants NS09518 and AG05681. KMC was also was supported by NIH GM07200, Medical Scientist.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kievit, J. and Kuypers, H.G. (1975). Basal forebrain and hypothalamic connections to frontal and parietal cortex in the rhesus monkey. Science 187, 660–662.
Bigl, V., Woolf, N.J. and Butcher, L.L. (1982). Cholinergic projections from the basal fore-brain to frontal, parietal, temporal, occipital, and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysis. Brain Res. Bull. 8, 727–749.
McKinney, M., Coyle, J.T. and Hedreen, J.C. (1983). Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system. J. Comp. Neurol. 217, 103–121.
Mesulam, M.-M., Mufson, E.J., Levey, A.I. and Wainer, B.H. (1983). Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J. Comp. Neurol. 214, 170–197.
Saper, C.B. (1984). Organization of cerebral cortical afferent systems in the rat. II. Magno-cellular basal nucleus. J. Comp. Neurol. 222, 313–342.
Gerfen, CR. and Sawchenko, P.E. (1984). An anterograde neuroanatomical tracing method that shows the detailed morphology of neurons, their axons and terminals: Immunohisto-chemical localization of an axonally transported plant lectin, Phaseolus vulgaris leucoagglutinin (PHA-L). Brain Res. 290, 219–238.
Price, J.L. and Stern, R. (1983). Individual cells in the nucleus basalis — diagonal band complex have restricted axonal projections to the cerebral cortex in the rat. Brain Res. 269, 352–356.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Kluwer Academic Publishers
About this chapter
Cite this chapter
Carnes, K.M., Price, J.L. (1988). Demonstration of Individual Fibers from the Substantia Innominata to the Frontal Cortex of the Rat, Using Phaseolus Vulgaris Leucoagglutinin (PHA-L). In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_15
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1721-0_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8969-2
Online ISBN: 978-1-4613-1721-0
eBook Packages: Springer Book Archive