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Alpha- and Beta-Endopsychosins: Physiological Actions and Interactions with Excitatory Amino Acids

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Neurobiology of Amino Acids, Peptides and Trophic Factors

Part of the book series: Topics in the Neurosciences ((TINS,volume 8))

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Abstract

Phencyclidine (1-(1-cyclohexylphenyl)piperidine) was synthesized in 1957 by the Parke Davis company. Phencyclidine (PCP) is an excellent general anesthetic because it produces anesthesia with analgesia, while producing minimal cardiorespiratory depression. However, in clinical trials PCP was found to produce postanesthetic hallucinations, which could last more than 12 hours, in about 30% of patients [1]. Clinical use of PCP in humans was discontinued. Later, PCP was approved for use as a veterinary anesthetic and an analog, ketamine, was approved for use in humans. Although ketamine can produce psychotomimetic side effects, these are not as prolonged as with PCP.

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Authors
  1. Thomas H. Lanthorn
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  2. Debora A. Dimaggio
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  3. Patricia C. Contreras
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Editors and Affiliations

  1. Washington University School of Medicine, USA

    James A. Ferrendelli , Robert C. Collins  & Eugene M. Johnson ,  & 

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© 1988 Kluwer Academic Publishers

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Lanthorn, T.H. et al. (1988). Alpha- and Beta-Endopsychosins: Physiological Actions and Interactions with Excitatory Amino Acids. In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_13

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  • DOI: https://doi.org/10.1007/978-1-4613-1721-0_13

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  • Print ISBN: 978-1-4612-8969-2

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