Abstract
Previous studies on the radiosensitizing properties of the lapachol chelate of nickel suggested a possible chemosensitizing role for this complex. Hypoxic mammalian cells become more sensitive to the toxic action of cisplatin when also treated with nickel-lapachol. There is less sensitizing effect in aerobic cells; lapachol alone shows less effect than its nickel complex. It is suggested that the interaction occurs at the DNA level.
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© 1988 Martinus Nijhoff Publishing, Boston
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Skov, K.A., Adomat, H., Farrell, N.P. (1988). Effects of Nickel-Lapachol in Hypoxic Cells. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_85
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_85
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