Metal Ions Complexation Properties of Antitumor Athracyclines. Different Cyto and Cardiotoxicity of Copper(II) Chelates
The anthracycline antitumour drugs are thought to display their therapeutic action through cytotoxic radicals. The enzymatic generation of carbon centered radicals, possibly followed by an electron transfer from the semiquinone radical to the molecular oxygen, has been suggested as a step in drug induced cell damage(1). Very recently an alternative mechanism of “non enzymatic” O2 reduction was proposed, the coordination of anthracycline to a bivalent copper center having been indicated as an essential step to activate the drug(2).
KeywordsPlatinum Superoxide CaCl Doxorubicin DPPH
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