Advertisement

Metal Ions Complexation Properties of Antitumor Athracyclines. Different Cyto and Cardiotoxicity of Copper(II) Chelates

  • F. Morazzoni
  • L. Pellicciari-Bollini
  • F. Piccinini
  • E. Monti
  • L. Paracchini
  • R. Supino
Part of the Developments in Oncology book series (DION, volume 54)

Abstract

The anthracycline antitumour drugs are thought to display their therapeutic action through cytotoxic radicals. The enzymatic generation of carbon centered radicals, possibly followed by an electron transfer from the semiquinone radical to the molecular oxygen, has been suggested as a step in drug induced cell damage(1). Very recently an alternative mechanism of “non enzymatic” O2 reduction was proposed, the coordination of anthracycline to a bivalent copper center having been indicated as an essential step to activate the drug(2).

Keywords

Antitumour Effect Cardiotoxic Effect Carbon Centered Radical Automatic Temperature Control Antitumour Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lown, J.W., Chen, H. Can.J.Chem., 59, 3212, 1981CrossRefGoogle Scholar
  2. 2.
    Wallace, K.B. Toxicology and Applied Pharmacology, 86, 69, 1986PubMedCrossRefGoogle Scholar
  3. 3.
    Monti, E., Piccinini, F., Favalli, L., Villani, F., Biochem.Pharmacol. 32, 3303, 1983PubMedCrossRefGoogle Scholar
  4. 4.
    Malatesta, V., Morazzoni, F., Gervasini, A.Arcamone, F., Anticancer Drug Design, 1, 53, 1985Google Scholar
  5. 5.
    Malatesta, V., Gervasini, A.Morazzoni, F., Inorg.Chim.Acta, 136, 81, 1987CrossRefGoogle Scholar
  6. 6.
    Morazzoni, F., Gervasini, A., Malatesta, V., Inorg.Chim.acta, 136, 111, 1987CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • F. Morazzoni
  • L. Pellicciari-Bollini
  • F. Piccinini
  • E. Monti
  • L. Paracchini
  • R. Supino

There are no affiliations available

Personalised recommendations