Hepatic Arterial Infusion of Cisplatin as a Single Agent or in Combination with Vinblastine for Breast Cancer Metastatic to the Liver

  • G. Fraschini
  • G. Fleishman
  • H. Carrasco
  • C. Charnsangavej
  • G. Hortobagyi
Part of the Developments in Oncology book series (DION, volume 54)


Breast cancer patients with hepatic metastases that are refractory to front-line chemotherapy respond poorly to additional systemic therapy. In a study of more than 100 patients treated with systemic continuous infusion vinblastine (V) we observed a 37% overall response rate, but responses were documented in only 13% of the hepatic metastases (1). Regional delivery may allow to increase the tumor exposure to suitable antitumor agents. The reported trials of intraarterial regional chemotherapy have generally shown some advantage for this delivery route (2).


Breast Cancer Patient Hepatic Metastasis Minor Response Paralytic Ileus Hepatic Arterial Infusion 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • G. Fraschini
  • G. Fleishman
  • H. Carrasco
  • C. Charnsangavej
  • G. Hortobagyi

There are no affiliations available

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