Macromolecular Antitumor Drugs: Pharmacology and Biology
After 20 years of research we got insight into the molecular pharmacodynamic of platinum drugs, i.e. we can draw the structure of the complex formed between the platinum atom and the DNA molecule which is responsible for the cytostatic effect. We have also collected enough evidence supporting the hypothesis that the block of cytokinesis is part of a complex cellular response to specific DNA damage induced by platinum coordination compounds with cis-position of leaving ligands.
KeywordsSugar Toxicity Filtration Platinum Chlorine
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