Macromolecular Antitumor Drugs: Pharmacology and Biology

  • J. Drobnik
Part of the Developments in Oncology book series (DION, volume 54)

Abstract

After 20 years of research we got insight into the molecular pharmacodynamic of platinum drugs, i.e. we can draw the structure of the complex formed between the platinum atom and the DNA molecule which is responsible for the cytostatic effect. We have also collected enough evidence supporting the hypothesis that the block of cytokinesis is part of a complex cellular response to specific DNA damage induced by platinum coordination compounds with cis-position of leaving ligands.

Keywords

Sugar Toxicity Filtration Platinum Chlorine 

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Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • J. Drobnik

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