Macromolecular Antitumor Drugs: Pharmacology and Biology

  • J. Drobnik
Part of the Developments in Oncology book series (DION, volume 54)


After 20 years of research we got insight into the molecular pharmacodynamic of platinum drugs, i.e. we can draw the structure of the complex formed between the platinum atom and the DNA molecule which is responsible for the cytostatic effect. We have also collected enough evidence supporting the hypothesis that the block of cytokinesis is part of a complex cellular response to specific DNA damage induced by platinum coordination compounds with cis-position of leaving ligands.


Platinum Complex Carrier Polymer Cytostatic Effect Platinum Drug Platinum Atom 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1988

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  • J. Drobnik

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