Platinum Coordination Derivatives by the Intraperitoneal Route: Pharmacokinetics and Clinical Results
Notwithstanding improvement of treatment results in ovarian cancer, even the patient who achieved a complete remission may face a relapse. The seven year follow-up figures of the study performed in the Netherlands (1), which compared cisplatin containing combination chemotherapy CHAP-5 (cyclophosphamide, hexamethylmelamine, adriamy-cin and cisplatin) with HexaCAF (hexamethylmelamine, cyclophosphamide, adriamycin and 5-flourouracil) show a steadily decrease of the number of disease free patients upto 60–70% of those formerly in complete remission. Therefore even for patients in complete remission as a result of cisplatin based combination chemotherapy new treatment strategies seem warranted. For the other, not reaching a complete remission this counts the more. Late intensification by an increased dose of cisplatin for instance could offer such a new treatment avenue, based on the theory of Goldie and Coldman (2). Such an increased dose might overcome acquired cisplatin resistance of remaining tumorcells.
KeywordsToxicity Platinum Resi Cyclophosphamide Thrombocytopenia
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