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Abstract

The Flaviviridae are the most medically important group of arthropod-borne viruses. Previously classified as members of the Togaviridae, in 1984 flaviviruses were put into the new virus family Flaviviridae (1). This reclassification was the result of recent research that clearly demonstrated the significant differences in genome structure, gene order, replication strategy and virus morphogenesis between the flaviviruses and other togaviruses. Because of inherent, as well as technical difficulties, the analysis of flaviviruses at the molecular level has been particularly slow. However, the recent successful cloning and sequencing of several flavivirus genomes (2, 3, 4) has dramatically increased our knowledge of the genetic organization of the flaviviruses. Current research efforts are focused on identifying the proteases which are responsible for processing the viral precursor polypeptide, characterizing the functions of the 7 viral non-structural proteins, delineating the nucleic acid signals which regulate viral RNA transcription, determining whether host cell proteins function as components of the viral replication complexes, and analyzing viral mutations which affect virulence.

Keywords

West Nile Virus Japanese Encephalitis Virus Cerebral Spinal Fluid Japanese Encephalitis Virus Japanese Encephalitis Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Westaway, E.G., Brinton, M.A., Gaidamovich, S.Ya., Horzinek, M.C., Igarashi, A., Kaariainen, L., Lvov, D.K., Porterfield, J.S., Russell, P.K., and Trent, D.W. Intervirology 24, 183–192, 1986.Google Scholar
  2. 2.
    Rice, C.M, Lenches, E.M., Eddy, S.R., Shin, S.J., Sheets, R.L., and Strauss, J.H. Science 229, 726–733, 1985.PubMedGoogle Scholar
  3. 3.
    Castle, E., Leidner, U., Nowak, T., Wengler, G., and Wengler, G. Virology 149, 10–26, 1986.PubMedGoogle Scholar
  4. 4.
    Zhao, B., Mackow, E., Buckler-White, A., Markoff, L., Chanock, R.M., Lai, C-J., and Makino, Y. Virology 155, 77–88, 1986.PubMedGoogle Scholar
  5. 5.
    Shope, R.E. In: The Togaviruses. (Ed. R.W. Schlesinger) Academic Press, New York, 1980, pp. 47–82.Google Scholar
  6. 6.
    Monath, T.P.In: Virology (Ed. B.N. Fields) Raven Press, New York, 1985, pp. 955–1004.Google Scholar
  7. 7.
    Monath, T.P.In: : The Togaviridae and Flaviviridae (Eds. S. Schlesinger and M. Schlesinger)., Plenum Publishing Corporation, New York, 1986, pp. 375–440.Google Scholar
  8. 8.
    Halstead, S.B. Am. J. Epidemiol. 114, 632–648, 1981.PubMedGoogle Scholar
  9. 9.
    Grimstad, P.R., Ross, Q.E., and Craig, G.B. Jr., J. Med. Entomol. 17, 1–17, 1980.PubMedGoogle Scholar
  10. 10.
    Eckels, K.H., Brandt, W.E., Harrison, V.R., McConn, J.M., and Russell, P.K. Infect. Immun. 14, 1221–1227, 1976.PubMedGoogle Scholar
  11. 11.
    Trent, D.W., Grant, J.A., Vorndam, A.V. and Monath, T.P. Virology 114, 319–332, 1981.PubMedGoogle Scholar
  12. 12.
    Malkova, D. Acta. Virol. (Praha) 4, 233, 1960.Google Scholar
  13. 13.
    Huang, C.H. and Wong, C. Acta. Virol. (Praha) 7, 322–330, 1963.Google Scholar
  14. 14.
    Nathanson, N. In: St. Louis encephalitis (Ed. T.P. Monath), APHA, Washington, D.C., 1980, pp. 201–236.Google Scholar
  15. 15.
    Zisman, B., Wheelock, E.F., and Allison, A.C. J. Immunol. 107, 236–243, 1971.PubMedGoogle Scholar
  16. 16.
    Monath, T.P., Cropp, C.B., and Harrison, B.S. Lab. Invest. 48, 399–410, 1983.PubMedGoogle Scholar
  17. 17.
    Gardner, J.J. and Reyes, M.G.In: St. Louis encephalitis (Ed. T.P. Monath), APHA, Washington, D.C., 1980, pp. 551–570.Google Scholar
  18. 18.
    Reyes, M.G., Gardner, J.J., Poland, J.D. Arch. Neruol. 38, 329–334, 1981.Google Scholar
  19. 19.
    Buescher, E.L. and Scherer W.F. Am. J. Trop. Med. Hyg. 8, 719–722, 1959.PubMedGoogle Scholar
  20. 20.
    Chaturvedi, U.C., Mathur, A., Chandra, A., Das, S.K., Tandon, H.O. and Singh, U.K. J. Infect. Dis. 141, 712–715, 1980.PubMedGoogle Scholar
  21. 21.
    Dickerson, R.B., Newton, J.R., and Hansen, J.E. Am. J. Med. 12, 277–290, 1952.PubMedGoogle Scholar
  22. 22.
    Shiraki, H. In: Clinical Virology (Eds. R. Debre and J. Celers), Saunders, Philadelphia, 1970, pp. 156–175.Google Scholar
  23. 23.
    Ketel, W.B. and Ognibene, A.J. Am. J. Med. Sci. 26, 271–279, 1971.Google Scholar
  24. 24.
    Miyake, M., Bull. WHO 30, 153–160, 1964.PubMedGoogle Scholar
  25. 25.
    Edelman, R. and Paryanonda, A. Am. J. Epidemiol. 98, 29–38, 1973.PubMedGoogle Scholar
  26. 26.
    Burke, D.S. and Nisalak, A. J. Clin. Microbiol. 15, 353–361, 1982.PubMedGoogle Scholar
  27. 27.
    Rubin, S.G. and Chumakov, M.P. Zentralbl. Bakteriol. (Suppl. 9), 231–236.Google Scholar
  28. 28.
    Heinz, F.X. and Kunz, C. J. Gen. Virol. 62, 271–285, 1982.PubMedGoogle Scholar
  29. 29.
    Trent, D.W., Grant, J.A., Vorndam, A.V. and Monath, J.P. Virology 114, 319–332, 1981.PubMedGoogle Scholar
  30. 30.
    Trent, D.W., Grant, J.A., Rosen, L., and Monath, T.P. Virology 128, 271–284, 1983.PubMedGoogle Scholar
  31. 31.
    Blaskovic, D., Pucekova, G. and Kubinyi, L. Bull. WHO 36, 89–94, 1967.PubMedGoogle Scholar
  32. 32.
    Gresikova, M., Sekeyova, M., Stupalova, S. and Necas, S. Intervirology 5, 57–61, 1975.PubMedGoogle Scholar
  33. 33.
    Gresikova, M. and Beran, G.W.In: CRC Handbook Series in Zoonoses, Section B: Viral Zoonoses, Vol. I (Ed. G.W. Beran) CRC Press, Boca Raton, Florida, 1981, pp. 201–208.Google Scholar
  34. 34.
    Radsel-Medvescek, A., Marolt-Gomiscek, M., and Gajsek-Zima, M. Zentralbl. Bakteriol. (Suppl. 9): 277–280, 1980.Google Scholar
  35. 35.
    Pogodina, V.V., Levina, L.S., Fokina, G.I., Koreshkova, G.V., Malenko, G.V., Bochkova, N.G., and Rzhakhowa, O.E. Acta Virol. 25, 352–360, 1981.PubMedGoogle Scholar
  36. 36.
    Price, W.H., Virology 29, 679–801, 1966.PubMedGoogle Scholar
  37. 37.
    Zlotnik, I., Grant, D.P., and Carter, G.B. Br. J. Exp. Pathol. 57, 200–210, 1976.Google Scholar
  38. 38.
    Ogawa, M., Okubo, H., Tsuji, Y., Yasui, N., and Someda, K.J. Neurol. Sci. 19, 363–373, 1973.Google Scholar
  39. 39.
    Mueller, W.K. and Schaltenbrand, G. J. Neurol. 220, 1–20, 1979.Google Scholar
  40. 40.
    Lopes, O., Coimbra, T.L.M., Sacchetta, L. deA., and Calisher, C.H. Am. J. Epidemiol. 107, 444–449, 1978.Google Scholar
  41. 41.
    Lopes, O., Sacchetta, L. deA., Coimbra, T.L.M., Pinto, G.H., and Glasser, C.M., Am. J. Epidemiol. 108, 394–401, 1978.Google Scholar
  42. 42.
    Doherty, R.L., Aust. J. Exp. Biol. Med. Sci. 55, 103–130, 1977.PubMedGoogle Scholar
  43. 43.
    Essed, W.C.A.H., and Van Tongeren, H.A.E. Trop. Geogr. Med. 17, 52–55, 1965.PubMedGoogle Scholar
  44. 44.
    Bennett, N.McK., Med. J. Aust. 2, 446–450, 1976.PubMedGoogle Scholar
  45. 45.
    Webb, H.E. and Rao, R.L. Trans. R. Soc. Trop. Med. Hyg. 55, 284–298, 1961.PubMedGoogle Scholar
  46. 46.
    Murphy, F.A., Iris The Togaviruses. (Ed. R.W. Schlesinger) Academic Press, New York, 1980, pp. 241–316.Google Scholar
  47. 47.
    Smith, G.W. and Wright, P.J., J. Gen. Virol. 66 559–571, 1985.PubMedGoogle Scholar
  48. 48.
    Schlesinger, J.J., Brandriss, M.W., and Monath, T.P. Virology 125, 8–17, 1983.PubMedGoogle Scholar
  49. 49.
    Shapiro, D., Brandt, W.E., and Russell, P.K., Virology 50, 906–911, 1972.PubMedGoogle Scholar
  50. 50.
    Stephenson, J.R., Lee, J.M., and Wilton-Smith, P.D., J. Gen. Virol. 62, 81–89, 1984.Google Scholar
  51. 51.
    Heinz, F.X., Berger, R., Turna, W., and Kunz, C. Virology 126, 525–537, 1983.PubMedGoogle Scholar
  52. 52.
    Peiris, J.S.M., Porterfield, J.S., and Roehrig, J.T., J. Gen. Virol. 58, 283–289, 1982.PubMedGoogle Scholar
  53. 53.
    Roehrig, J.T., Mathews, J.H., and Trent, D.W., Virology 128, 118–126, 1983.PubMedGoogle Scholar
  54. 54.
    Henchal, E.A., Gentry, M.K., McCown, J.M., and Brandt, W.E., Am. J. Trop. Med. Hyg. 31, 830–836, 1982.PubMedGoogle Scholar
  55. 55.
    Rossmann, M.G., Arnold, E., Erickson, J.W., Frankenberger, E.A., Griffith, J.P., Hecht, H-J., Johnson, J.E., Kamer, G., Luo, M., Mosser, A.G., Rueckert, R.R., Sherry, B., and Vriend, G. Nature 317, 145–153, 1985.PubMedGoogle Scholar
  56. 56.
    Luo, M., Vriend, G., Kamer, G., Minor, I., Arnold, E., Rossman, M.G., Boege, U., Scraba, D.G., Duke, G.M., and Palmenberg, A.C. Science 235, 182–191, 1987.PubMedGoogle Scholar
  57. 57.
    Hogle, J.M., Chow, M., and Filman, D.J., Science 229, 1358–1365, 1985.PubMedGoogle Scholar
  58. 58.
    Gollins, S.W. and Porterfield, J.S. J. Gen. Virol. 67, 1941–1950, 1986.PubMedGoogle Scholar
  59. 59.
    Gollins, S.W. and Porterfield, J.S. J. Gen. Virol. 67, 157–166, 1986.PubMedGoogle Scholar
  60. 60.
    Cleaves, G.R., Ryan, T.E., and Schlesinger, R.W. Virology 111, 73–83, 1981.PubMedGoogle Scholar
  61. 61.
    Deubel, V., Crouset, J., Benichou, D., Digoutte, J.-P., Bouloy, M., and Girard, M., Ann. Virol. 134E, 581–588, 1983.Google Scholar
  62. 62.
    Cleaves, G.R. and Dubin, D.T., Virology 96, 159–165, 1979.PubMedGoogle Scholar
  63. 63.
    Wengler, G., Wengler, G., and Gross, H.J., Virology 89, 423–437, 1978.PubMedGoogle Scholar
  64. 64.
    Wengler, G. and Wengler, G., Virology 113, 544–555, 1981.PubMedGoogle Scholar
  65. 65.
    Brinton, M.A., Fernandez, A.V., and Dispoto, J.H., Virology 153, 113–121, 1986.PubMedGoogle Scholar
  66. 66.
    Rueckert, R. In: Virology (Ed. B.N. Fields) Raven Press, New York, 1985, pp. 705–738.Google Scholar
  67. 67.
    Brinton, M.A. and Dispoto, J.H. Virology, 162, 290–299, 1988.PubMedGoogle Scholar
  68. 68.
    Strauss, E.G. and Strauss, J.H., Curr. Top. Microbiol. Immunol. 105, 1–98, 1983.PubMedGoogle Scholar
  69. 69.
    Dalgarno, L., Trent, D.W., Strauss, J.H., and Rice, CM., J. Mol. Biol. 187, 309–323, 1986.PubMedGoogle Scholar
  70. 70.
    Rice, C.M., Strauss, E.G. and Strauss, J.H.In: Togaviridae and Flaviviridae, the viruses (Eds. S. Schlesinger and M. Schlesinger), Plenum Publishing Corp., New York, 1986, pp. 279–326.Google Scholar
  71. 71.
    Lubiniecki, A.S. and Henry, C.J., Proc. Soc. Exp. Biol. Med. 145, 1165–1169, 1974.PubMedGoogle Scholar
  72. 72.
    Ng, M.L., Pederson, J.S., Toh, B.H., and Westaway, E.G., Arch. Virol. 78, 177–190, 1983.PubMedGoogle Scholar
  73. 73.
    Brinton, M.A.In: Togaviridae and Flaviviridae, the viruses (Eds. S. Schlesinger and M. Schlesinger), Plenum Publishing Corp., New York, 1986, pp. 329–376.Google Scholar
  74. 74.
    Chu, P.W.G. and Westaway, E.G., Virology 140, 68–79, 1984.Google Scholar
  75. 75.
    Grun, J.B. and Brinton, M.A. J. Virol. 60, 1113–1124, 1986.PubMedGoogle Scholar
  76. 76.
    Grun, J.B. and Brinton, M.A., J. Virol. 61, 3641–3644, 1987.PubMedGoogle Scholar
  77. 77.
    Landers, T.A., Blumenthal, T., and Weber, K., J. Biol. Chem. 249, 5801–5808.Google Scholar
  78. 78.
    Blumenthal, J. Methods Enzymol. 60, 628–638, 1979.PubMedGoogle Scholar
  79. 79.
    Dasgupta, A., Zabel, P. and Baltimore, D. Cell 19, 423–429, 1980.PubMedGoogle Scholar
  80. 80.
    Morrow, C.D., Lubinski, J., Hocko, J., Gibbons, G.F. and Dasgupta, A. J. Virol. 53, 266–272, 1985.PubMedGoogle Scholar
  81. 81.
    Brinton, M.A. J. Virol. 46, 860–870, 1983.PubMedGoogle Scholar
  82. 82.
    Brinton, M.A., Blank, K.J., and Nathanson, N. In: Concepts in viral pathogenesis (Eds. A.L. Notkins and M.B.A. Oldstone), Springer Verlag, New York, pp. 71–78, 1984.Google Scholar
  83. 83.
    Smith, A., Am. J. Trop. Med. Hyg. 30, 1319–1323, 1981.PubMedGoogle Scholar
  84. 84.
    Reid, H.W. J. Comp. Pathol. 85, 223–229, 1975.Google Scholar
  85. 85.
    Reid, H.W. and Moss, R. Int Arbovirus in the Mediterranean Countries (eds. J. Vesenjak-Hirjan; J.S. Porterfield, and E. Arslanagic), Abh. Bakteriol. Suppl. 9, pp. 219–223, 1980.Google Scholar
  86. 86.
    Warren, A.J. In: Yellow Fever (ed. G.K. Strode), McGraw-Hill, New York, pp. 6–37, 1951.Google Scholar
  87. 87.
    Huang, C.H. Adv. Virus Res. 27, 71–101, 1982.PubMedGoogle Scholar
  88. 88.
    Monath, T.P., Cropp, C.B., Bowen, G.S., Kemp, G.E., Mitchell, C.J., and Gardner, J.J., Am. J. Trop. Med. Hyg. 29, 948–962, 1980.PubMedGoogle Scholar
  89. 89.
    Fitzgeorge, R. and Bradish, C.J. J. Gen. Virol. 46, 1–13, 1980.PubMedGoogle Scholar
  90. 90.
    Bowen, G.S., Monath, T.P., Kemp, G.E., Kerschner, J.H., and Kirk, L.J. Am. J. Trop. Med. Hyg. 29, 1411–1419, 1980.PubMedGoogle Scholar
  91. 91.
    Mitchell, C.J., Gubler, D.J., and Monath, T.P., J. Med. Entomol. 20, 526–533, 1983.PubMedGoogle Scholar
  92. 92.
    Parks, J.J., Ganaway, J.R. and Price, W.H. Am. J. Hyg. 68, 106–119, 1958.PubMedGoogle Scholar
  93. 93.
    Holland, J.J. In: Concepts in Viral Pathogenesis (eds. A.L. Notkins and M.B.A. Oldstone), Springer-Verlag, New York, pp. 137–143, 1984.Google Scholar
  94. 94.
    Trent, D.W., Monath, T.P., Bowen, G.S., Vorndam, A.V., Cropp, C.B. and Kemp, G.E. Ann. N.Y. Acad. Sci. 354, 219–237, 1980.PubMedGoogle Scholar
  95. 95.
    Guirakhoo, F. and Heinz, F. J. Gen. Virol. 67,859–864, 1987.Google Scholar
  96. 96.
    Davis, N.L., Fuller, F.J., Dougherty, W.G., Olmsted, R.A., and Johnston, R.E. PNAS 83, 6771–6775, 1986.PubMedGoogle Scholar
  97. 97.
    Dietzschold, B., Wunner, W.H., Wiktor, T.J., Lopes, A.D., Lafon, M., Smith, CL., and Koprowski, H. PNAS 80, 70–74, 1983.PubMedGoogle Scholar
  98. 98.
    Schmaljohn, C. and Blair, C.D. J. Virol. 24, 580–589, 1977.PubMedGoogle Scholar
  99. 99.
    Katz, E. and Goldblum, N. Arch. Gesamte. Virusforsch. 25, 69–82, 1968.PubMedGoogle Scholar
  100. 100.
    Brinton, M.A. Virology 116, 84–98, 1982.PubMedGoogle Scholar
  101. 101.
    Matthews, J.H. and Vorndam, A.V. J. Gen. Virol. 61, 177–186, 1982.Google Scholar
  102. 102.
    Kuno, G. Intervirology 18, 45–55, 1982.PubMedGoogle Scholar
  103. 103.
    Brinton, M.A., Davis, J. and Schaefer, D. Virology 140, 152–158, 1985.PubMedGoogle Scholar
  104. 104.
    Webster, L.T. and Clow, A.D. J. Exp. Med. 63, 827–845, 1936.PubMedGoogle Scholar
  105. 105.
    Slavin, H.B. J. Bacteriol. 46, 113–118, 1943.PubMedGoogle Scholar
  106. 106.
    Hotta, H., Murakami, I., Miyasaki, K., Takeda, Y., Shirane, H., and Hotta, S. J. Gen. Virol. 52, 71–76, 1981.PubMedGoogle Scholar
  107. 107.
    Mathur, A., Arora, K.L., and Chaturvedi, U.C. J. Gen. Virol. 59, 213–217, 1982.PubMedGoogle Scholar
  108. 108.
    Malenko, G.V., Fokina, G.I., Levina, L.S., Mamonenko, L.E., Rzhakhova, O.E., Pogodina, V.V. and Frolova, M.P. Acta Virol. 26, 362–368, 1982.PubMedGoogle Scholar
  109. 109.
    Fokina, G.I., Malenko, G.V., Levina, L.S., Koreshkova, G.V., Rzhakhova, O.E., Mamonenko, L.L., Pogodina, V.V. and Frolova, M.P. Acta. Virol. 26, 369–375, 1982.PubMedGoogle Scholar
  110. 110.
    Frolova, M.P. and Pogodina, V.V. Acta Virol. 28, 232–239, 1984.PubMedGoogle Scholar
  111. 111.
    Pogodina, V.V., Frolova, M.P., Malenko, G.V., Fokina, G.I., Koreshkova, L.L., Kiseleva, N.G., Bochkova, N.G. and Ralph, N.M. Arch. Virol. 75, 71–86, 1983.PubMedGoogle Scholar
  112. 112.
    Edelman, R., Schneider, R.J., Vejjajiva, A., Pornpibul, R., and Voodhikul, P. Am. J. Trop. Med. Hyg. 23, 733–738, 1976.Google Scholar
  113. 113.
    Monath, T.P. Am. J. Epidemiol. 93, 122–129, 1971.PubMedGoogle Scholar
  114. 114.
    Weiner, L.P., Cole, G.A., and Nathanson, N. J. Hyg. 68, 435–446, 1970.Google Scholar
  115. 115.
    Albrecht, P. In: Biology of Viruses of the Tick-borne encephalitis complex (Ed. H. Libikova), Academic Press, New York, pp. 247–257, 1960.Google Scholar
  116. 116.
    Peck, J.L. Jr. and Savin, A.B. J. Exp. Med. 85, 647–662, 1947.PubMedGoogle Scholar
  117. 117.
    Speight, C., Coia, G., Parker, M.D., and Westaway, E.B. J. Gen. Virol. 69, 23–34, 1988.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • M. Brinton
    • 1
  1. 1.The Wistar InstitutePhiladelphiaUSA

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