Papovavirus Infections of the Nervous System

  • John E. Greenlee
Part of the Developments in Medical Virology book series (DIMV, volume 5)


Papovaviruses are DNA viruses which are divided into two genera, papillomaviruses and polyomaviruses. Papillomaviruses, although widely distributed in human and animal species, are not known to invade the central nervous system. Polyomaviruses, on the other hand, produce an opportunistic, demyelinating infection of immunocompromised patients, progressive multifocal leukoencephalopathy (PML) and have been suggested as etiologic agents of human brain tumors. The present chapter deals with the role of the polyoma subgroup of papovaviruses in human systemic and central nervous system infection, discusses human and animal data pertaining to the pathogenesis of PML, and reviews the possible role of these agents in central nervous system neoplasia.


Progressive Multifocal Leukoencephalopathy Progressive Multifocal Leukoencephalopathy Polyoma Virus SV40 Virus Progressive Multifocal Leukoencephalopathy Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • John E. Greenlee
    • 1
  1. 1.Neurology Service and Neurovirology Research Laboratory, Veterans Administration Medical Center and Department of NeurologyUniversity of Utah Medical SchoolSalt Lake CityUSA

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